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https://hdl.handle.net/2440/130936
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Type: | Journal article |
Title: | The utility of assessing health-related quality of life to predict cognitive decline and dementia |
Author: | Phyo, A.Z.Z. Gonzalez-Chica, D.A. Stocks, N.P. Storey, E. Woods, R.L. Murray, A.M. Orchard, S.G. Shah, R.C. Gasevic, D. Freak-Poli, R. Ryan, J. ASPREE Investigator Group, |
Citation: | Journal of Alzheimer's Disease, 2021; 80(2):895-904 |
Publisher: | IOS Press |
Issue Date: | 2021 |
ISSN: | 1387-2877 1875-8908 |
Statement of Responsibility: | Aung Zaw Zawa Phyo, David A. Gonzalez-Chica, Nigel P. Stocks, Elsdona Storey, Robyn L. Woods, Anne M. Murray … et al. |
Abstract: | BACKGROUND: Health-related quality of life (HRQoL) has been shown to predict adverse health outcome in the general population. OBJECTIVE: We examined the cross-sectional association between HRQoL and cognitive performance at baseline. Next, we explored whether baseline HRQoL predicted 5-year incident cognitive decline and dementia and whether there were gender differences. METHODS: 19,106 community-dwelling participants from the ASPirin in Reducing Events in the Elderly (ASPREE) trial, aged 65-98 years, free of major cognitive impairments, and completed the HRQoL 12-item short-form (SF-12) at baseline (2010-2014), were followed until June 2017. The physical (PCS) and mental component scores (MCS) of SF-12 were calculated. The cognitive tests were assessed at baseline, year 1, 3, 5, and 7 or close-out visit. Cognitive decline was defined as > 1.5 SD drop from baseline on any of the cognitive tests. Dementia was adjudicated according to DSM-IV criteria. Linear and Cox proportional-hazards regressions were used to examine the cross-sectional and longitudinal associations respectively. RESULTS: At baseline, higher PCS and MCS were associated with better cognition. Over a median 4.7-year follow-up, higher MCS was associated with a reduced risk of cognitive decline and dementia (12% and 15% respectively, per 10-unit increase) and a 10-unit higher PCS was associated with a 6% decreased risk of cognitive decline. PCS did not predict dementia incidence. Findings were not different by gender. CONCLUSION: Our study found that higher HRQoL, in particular MCS, predicted a reduced risk of cognitive decline and dementia over time in community-dwelling older people. |
Keywords: | Cognition cognitive dysfunction dementia health-related quality of life (HRQoL) quality of life |
Rights: | © 2021 – IOS Press. All rights reserved. |
DOI: | 10.3233/JAD-201349 |
Published version: | http://dx.doi.org/10.3233/jad-201349 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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