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Type: Journal article
Title: The utility of assessing health-related quality of life to predict cognitive decline and dementia
Author: Phyo, A.Z.Z.
Gonzalez-Chica, D.A.
Stocks, N.P.
Storey, E.
Woods, R.L.
Murray, A.M.
Orchard, S.G.
Shah, R.C.
Gasevic, D.
Freak-Poli, R.
Ryan, J.
ASPREE Investigator Group
Citation: Journal of Alzheimer's Disease, 2021; 80(2):895-904
Publisher: IOS Press
Issue Date: 2021
ISSN: 1387-2877
Statement of
Aung Zaw Zawa Phyo, David A. Gonzalez-Chica, Nigel P. Stocks, Elsdona Storey, Robyn L. Woods, Anne M. Murray … et al.
Abstract: BACKGROUND: Health-related quality of life (HRQoL) has been shown to predict adverse health outcome in the general population. OBJECTIVE: We examined the cross-sectional association between HRQoL and cognitive performance at baseline. Next, we explored whether baseline HRQoL predicted 5-year incident cognitive decline and dementia and whether there were gender differences. METHODS: 19,106 community-dwelling participants from the ASPirin in Reducing Events in the Elderly (ASPREE) trial, aged 65-98 years, free of major cognitive impairments, and completed the HRQoL 12-item short-form (SF-12) at baseline (2010-2014), were followed until June 2017. The physical (PCS) and mental component scores (MCS) of SF-12 were calculated. The cognitive tests were assessed at baseline, year 1, 3, 5, and 7 or close-out visit. Cognitive decline was defined as > 1.5 SD drop from baseline on any of the cognitive tests. Dementia was adjudicated according to DSM-IV criteria. Linear and Cox proportional-hazards regressions were used to examine the cross-sectional and longitudinal associations respectively. RESULTS: At baseline, higher PCS and MCS were associated with better cognition. Over a median 4.7-year follow-up, higher MCS was associated with a reduced risk of cognitive decline and dementia (12% and 15% respectively, per 10-unit increase) and a 10-unit higher PCS was associated with a 6% decreased risk of cognitive decline. PCS did not predict dementia incidence. Findings were not different by gender. CONCLUSION: Our study found that higher HRQoL, in particular MCS, predicted a reduced risk of cognitive decline and dementia over time in community-dwelling older people.
Keywords: Cognition
cognitive dysfunction
health-related quality of life (HRQoL)
quality of life
Rights: © 2021 – IOS Press. All rights reserved.
DOI: 10.3233/JAD-201349
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