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https://hdl.handle.net/2440/132918
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Type: | Journal article |
Title: | Nanoparticle-stabilized oxygen microcapsules prepared by interfacial polymerization for enhanced oxygen delivery |
Author: | Wu, B. Sun, Z. Wu, J. Ruan, J. Zhao, P. Liu, K. Zhao, C.X. Sheng, J. Liang, T. Chen, D. |
Citation: | Angewandte Chemie International Edition, 2021; 60(17):9284-9289 |
Publisher: | Wiley |
Issue Date: | 2021 |
ISSN: | 1433-7851 1521-3773 |
Statement of Responsibility: | Baiheng Wu, Zhu Sun, Jiangchao Wu, Jian Ruan, Peng Zhao, Kai Liu, Chun-Xia Zhao, Jianpeng Sheng, Tingbo Liang, and Dong Chen |
Abstract: | Most tumors have more severe hypoxia levels than normal tissue; tumor hypoxia is thus a useful target for cancer treatment. Here, we develop an effective oxygen delivery vehicle of polydopamine-nanoparticle-stabilized oxygen microcapsules by interfacial polymerization. The oxygen microcapsules have excellent biocompatibility. Oxygen could easily diffuse out from the microcapsules, thus increasing and maintaining the microenvironment at an oxygen-rich state. In vitro cell cultures confirm that oxygen microcapsules could effectively improve the hypoxia microenvironment, showing the lowest fluorescent intensity of hypoxia-green-labeled cells. When injected subcutaneously in vivo, oxygen microcapsules could also improve the tumor's hypoxia microenvironment, thus suppressing the growth of tumor. Synergetic therapy using oxygen microcapsules and gemcitabine drugs is an effective way for tumor treatment, showing the best performance in suppressing the tumor's growth. |
Keywords: | Cancer therapy; drug delivery; microcapsule; oxygen delivery; synergetic therapy |
Rights: | © 2021 Wiley-VCH GmbH |
DOI: | 10.1002/anie.202100752 |
Grant ID: | http://purl.org/au-research/grants/arc/FT140100726 http://purl.org/au-research/grants/arc/DP200101238 |
Published version: | http://dx.doi.org/10.1002/anie.202100752 |
Appears in Collections: | Chemical Engineering publications |
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