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https://hdl.handle.net/2440/17451
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Type: | Journal article |
Title: | Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells |
Author: | Korten, Z. Cakouros, D. Kumar, S. |
Citation: | Journal of Biological Chemistry, 2005; 280(12):11981-11986 |
Publisher: | Amer Soc Biochemistry Molecular Biology Inc |
Issue Date: | 2005 |
ISSN: | 0021-9258 1083-351X |
Abstract: | The Drosophila steroid hormone ecdysone mediates cell death during metamorphosis by regulating the transcription of a number of cell death genes. The apical caspase DRONC is known to be transcriptionally regulated by ecdysone during development. Here we demonstrate that ecdysone also regulates the transcription of DRICE, a major effector caspase and a downstream target for DRONC in the fly. Using RNA interference in an ecdysone-responsive Drosophila cell line, we show that drice up-regulation is essential for apoptosis induced by ecdysone. We also show that drice expression is specifically controlled by the ecdysone-regulated transcription factor BR-C. Combined with previous observations, our results indicate that transcriptional regulation of the components of the core apoptotic machinery plays a key role in hormone-regulated programmed cell death during Drosophila development. |
Keywords: | Salivary Glands Cells, Cultured Animals Drosophila Ecdysone Caspases Drosophila Proteins Transcription Factors RNA, Messenger Apoptosis Up-Regulation Enzyme Activation |
DOI: | 10.1074/jbc.M413971200 |
Published version: | http://dx.doi.org/10.1074/jbc.m413971200 |
Appears in Collections: | Aurora harvest 2 Medicine publications |
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