New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry

Date

2006

Authors

Maclean, M.
Brinkworth, C.
Bilusich, D.
Bowie, J.
Doyle, J.
Llewellyn, L.
Tyler, M.

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Journal article

Citation

Toxicon, 2006; 47(6):664-675

Statement of Responsibility

Micheal J. Maclean, Craig S. Brinkworth, Daniel Bilusich, John H. Bowie, Jason R. Doyle, Lyndon E. Llewellyn and Michael J. Tyler

Conference Name

DOI

10.1016/j.toxicon.2006.01.019

Abstract

The skin secretion of the Dainty Green Tree Frog Litoria gracilenta contains 16 peptides, which protect the animal from predators, both large and small. A combination of negative and positive ion electrospray mass spectrometry together with Lys-C enzymic digest and Edman sequencing identifies three new wide-spectrum caerin 1 antibiotics, namely Caerin 1.17 [GLFSVLGSVAKHLLPHVAPIIAEKL-NH2], Caerin 1.18 [GLFSVLGSVAKHLLPHVVPVIAEKL-NH2], and Caerin 1.19 [GLFKVLGSVAKHLLPHVAPIIAEKL-NH2], and a narrow spectrum antibiotic Caerin 3.5 [GLWEKVKEKANELVSGIVEGVK-NH2].

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Copyright © 2006 Elsevier Ltd All rights reserved.

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https://doi.org/10.1016/j.toxicon.2006.01.019

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http://hdl.handle.net/2440/23548