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Type: Journal article
Title: Label-free bioaffinity detection using terahertz technology
Author: Mickan, S.
Menikh, A.
Liu, H.
Mannella, C.
MacColl, R.
Abbott, D.
Munch, J.
Zhang, X.
Citation: Physics in Medicine and Biology, 2002; 47(21):3789-3795
Publisher: IOP Publishing Ltd
Issue Date: 2002
ISSN: 0031-9155
Statement of
Samuel P Mickan, Abdellah Menikh, Haibo Liu, Carmen A Mannella, Robert MacColl, Derek Abbott, Jesper Munch and X-C Zhang
Abstract: We report the first use of differential terahertz time-domain spectroscopy for bioaffinity sensing. Binding is observed by measuring the transmission of a thin layer of biotin bound to the sensor protein avidin. We demonstrate the THz wave transmission of a sub-micron-thick film and sensitivity to 0.1 µg cm−2 of biotin. These results point the way for a host of biosensor applications using T-rays, or pulsed far-infrared (FIR) radiation.
Keywords: Macromolecular Substances; Avidin; Affinity Labels; Membranes, Artificial; Sensitivity and Specificity; Refractometry; Spectrum Analysis; Biosensing Techniques; Protein Binding; Biotin; Electromagnetic Phenomena; Surface Properties; Microwaves; Equipment Design
Description: © 2002 IOP Publishing
RMID: 0020021739
DOI: 10.1088/0031-9155/47/21/317
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Appears in Collections:Electrical and Electronic Engineering publications
Physics publications
Environment Institute publications

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