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Type: Journal article
Title: A 6-month study of the efficacy and safety of tadalafil in the treatment of erectile dysfunction: A randomised double-blind parallel-group placebo-controlled study in Australian men
Author: McMahon, C.
Stuckey, B.
Lording, D.
Wittert, G.
Murphy, A.
Shin, J.
Sutherland, P.
Palmer, N.
Lowy, M.
Jesudason, D.
Fredlund, P.
Citation: International Journal of Clinical Practice, 2005; 59(2):143-149
Publisher: Medicom International
Issue Date: 2005
ISSN: 1368-5031
Statement of
C.G. McMahon, B.G.A. Stuckey, D.W. Lording, G.A. Wittert, A. Murphy, J. Shin, P.D. Sutherland, N.R. Palmer, M.P. Lowy, D.R. Jesudason, P. Fredlund
Abstract: The efficacy and safety of tadalafil for the treatment of erectile dysfunction (ED) were assessed in a 6-month, randomised, double-blind, placebo-controlled study. Australian men with mild, moderate or severe ED of organic, psychogenic or mixed aetiology were randomised to tadalafil 20 mg as needed (n = 93) or placebo (n = 47). Efficacy assessments included the international index of erectile function (IIEF) and the sexual encounter profile (SEP) diary. Tadalafil significantly improved erectile function compared with placebo (p < 0.001, all measures). At the end of the study, the mean per-patient proportion of successful sexual intercourse attempts (SEP question three) was 73.5% for patients treated with tadalafil and 26.8% for placebo-treated patients. Improved erections were reported by 78% of tadalafil-treated patients compared to 12.8% of placebo-treated patients. The most common treatment-emergent adverse events--headache and dyspepsia--were generally mild or moderate. Tadalafil was effective and well tolerated in Australian men with mild to severe ED.
Keywords: Humans
Phosphodiesterase Inhibitors
Treatment Outcome
Double-Blind Method
Middle Aged
Erectile Dysfunction
Description: The definitive version is available at
DOI: 10.1111/j.1742-1241.2005.00451.x
Published version:
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