Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/42240
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Type: Journal article
Title: Free fatty acids have more potent effects on gastric emptying, gut hormones, and appetite than triacylglycerides
Author: Little, T.
Russo, A.
Meyer, J.
Horowitz, M.
Smyth, D.
Bellon, M.
Wishart, J.
Jones, K.
Feinle-Bisset, C.
Citation: Gastroenterology, 2007; 133(4):1124-1131
Publisher: W B Saunders Co
Issue Date: 2007
ISSN: 0016-5085
1528-0012
Statement of
Responsibility: 
Tanya J. Little, Antonietta Russo, James H. Meyer, Michael Horowitz, Douglas R. Smyth‡, Max Bellon‡, Judith M. Wishart, Karen L. Jones and Christine Feinle-Bisset
Abstract: BACKGROUND & AIMS: The effects of fat on gastric emptying (GE), gut hormones, and energy intake are dependent on digestion to free fatty acids (FFAs). In animals, small intestinal oleic acid inhibits energy intake more potently than the triacylglyceride (TG) triolein, but there is limited information about the comparative effects of FFA and TG in human beings. We compared the effects of FFA and TG on GE, gut hormone secretion, appetite, and energy intake in healthy males. METHODS: Nine men (age, 23 +/- 2 y; body mass index, 22 +/- 1 kg/m(2)) were studied on 3 occasions to evaluate the effects of (1) 40 g oleic acid (FFA, 1830 kJ), (2) 40 g macadamia oil (TG, 1856 kJ; both 600-mL oil-in-water emulsions stabilized with 4% milk protein and labeled with 15 MBq (123)I), or (3) 600 mL 4% milk protein (control, 352 kJ), administered intragastrically, on GE, plasma cholecystokinin (CCK) and peptide-YY (PYY) levels, appetite perceptions, and subsequent energy intake. RESULTS: GE of FFA was much slower than that of TG (P < .05), with greater retention of FFA, than TG, in the proximal stomach (P < .001). Hunger was less (P < .05), and fullness was greater (P < .05), after FFA when compared with control and TG. Increases in plasma CCK and PYY levels were greater after FFA than TG or control (P < .05). Energy intake tended to be less after FFA compared with TG (control, 4754 +/- 610 kJ; TG, 5463 +/- 662 kJ; FFA, 4199 +/- 410 kJ). CONCLUSIONS: FFAs empty from the stomach more slowly, but stimulate CCK and PYY and suppress appetite more potently than TG in healthy human beings.
Keywords: Gastrointestinal Tract; Humans; Macadamia; Gastrointestinal Hormones; Cholecystokinin; Peptide YY; Fatty Acids, Nonesterified; Oleic Acid; Triglycerides; Plant Oils; Milk Proteins; Appetite Depressants; Gastrointestinal Transit; Administration, Oral; Double-Blind Method; Appetite; Energy Intake; Gastric Emptying; Time Factors; Reference Values; Beverages; Adult; Male
Description: Copyright © 2007 AGA Institute Published by Elsevier Inc.
RMID: 0020073211
DOI: 10.1053/j.gastro.2007.06.060
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/623297/description#description
Appears in Collections:Medicine publications

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