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https://hdl.handle.net/2440/55097
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Type: | Journal article |
Title: | SHED: Stem cells from human exfoliated deciduous teeth |
Author: | Miura, M. Gronthos, S. Zhao, M. Lu, B. Fisher, L. Robey, P. Shi, S. |
Citation: | Proceedings of the National Academy of Sciences of USA, 2003; 100(10):5807-5812 |
Publisher: | Natl Acad Sciences |
Issue Date: | 2003 |
ISSN: | 0027-8424 1091-6490 |
Statement of Responsibility: | Masako Miura, Stan Gronthos, Mingrui Zhao, Bai Lu, Larry W. Fisher, Pamela Gehron Robey and Songtao Shi |
Abstract: | To isolate high-quality human postnatal stem cells from accessible resources is an important goal for stem-cell research. In this study we found that exfoliated human deciduous tooth contains multipotent stem cells [stem cells from human exfoliated deciduous teeth (SHED)]. SHED were identified to be a population of highly proliferative, clonogenic cells capable of differentiating into a variety of cell types including neural cells, adipocytes, and odontoblasts. After in vivo transplantation, SHED were found to be able to induce bone formation, generate dentin, and survive in mouse brain along with expression of neural markers. Here we show that a naturally exfoliated human organ contains a population of stem cells that are completely different from previously identified stem cells. SHED are not only derived from a very accessible tissue resource but are also capable of providing enough cells for potential clinical application. Thus, exfoliated teeth may be an unexpected unique resource for stem-cell therapies including autologous stem-cell transplantation and tissue engineering. |
Keywords: | Hippocampus Dentate Gyrus Mitochondria Stromal Cells Stem Cells Tooth, Deciduous Animals Humans Mice Mice, SCID Receptors, Cytoplasmic and Nuclear Transcription Factors DNA Primers Stem Cell Transplantation Transplantation, Heterologous Cell Separation Immunohistochemistry In Situ Hybridization Polymerase Chain Reaction Base Sequence Tooth Exfoliation |
DOI: | 10.1073/pnas.0937635100 |
Published version: | http://dx.doi.org/10.1073/pnas.0937635100 |
Appears in Collections: | Aurora harvest Medicine publications |
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