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Type: Journal article
Title: Different levels of neuroprotection by two insulin-like growth factor-I splice variants
Author: Aperghis, M.
Johnson, I.
Cannon, J.
Yang, S.
Goldspink, G.
Citation: Brain Research, 2004; 1009(1-2):213-218
Publisher: Elsevier Science Bv
Issue Date: 2004
ISSN: 0006-8993
Statement of
Michael Aperghis, Ian P. Johnson, John Cannon, Shi-Yu Yang and Geoffrey Goldspink
Abstract: We compared the neuroprotective effects of a liver-type isoform of insulin-like growth factor-I (IGF-IEa) and its splice variant, mechano-growth factor (MGF), isolated from active skeletal muscle. cDNAs of these peptides were injected into the facial muscle of adult rats prior to facial nerve avulsion. This resulted in significant neuroprotection of 88% and 37%, respectively, of motoneurons compared to control plasmid and avulsion-only groups. MGF is markedly more effective than the liver-type, systemic IGF-I for motoneuron survival, suggesting a major role for the peripheral target in adult neuronal maintenance and survival.
Keywords: Adult
Facial nerve
DOI: 10.1016/j.brainres.2004.02.049
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Appears in Collections:Anatomical Sciences publications
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