Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/57272
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Type: Journal article
Title: The genome sequence of Taurine cattle: a window to ruminant biology and evolution
Author: Bovine Genome Sequencing and Analysis Consortium
Elsik, C.
Tellam, R.
Worley, K.
Citation: Science, 2009; 324(5926):522-528
Publisher: American Association for the Advancement of Science
Issue Date: 2009
ISSN: 0036-8075
1095-9203
Contributor: Adelson, David Louis
Statement of
Responsibility: 
The Bovine Genome Sequencing and Analysis Consortium, Christine G. Elsik, Ross L. Tellam, Kim C. Worley
Abstract: To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
Keywords: Bovine Genome Sequencing and Analysis Consortium; Animals; Animals, Domestic; Cattle; Humans; Proteins; MicroRNAs; Sequence Analysis, DNA; Evolution, Molecular; Species Specificity; Alternative Splicing; Synteny; Genome; Molecular Sequence Data; Female; Male; Genetic Variation; Biological Evolution
Description: David L. Adelson is a member of The Bovine Genome Sequencing and Analysis Consortium.
Rights: Copyright 2009 by the American Association for the Advancement of Science; all rights reserved.
RMID: 0020095513
DOI: 10.1126/science.1169588
Appears in Collections:Molecular and Biomedical Science publications
Environment Institute publications

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