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Issue Date	Title	Author(s)
1995	A method for frequent measurement of sedation and analgesia in sheep using the response to a ramped electrical stimulus	Ludbrook, G.; Grant, C.; Upton, R.; Penhall, C.
2001	A mixture of alfentanil and morphine for rapid postoperative loading with opioid: theoretical basis and initial clinical investigation	Ludbrook, G.; Macintyre, P.; Douglas, H.; Ong, J.; Upton, R.
2010	A pharmacokinetic and pharmacodynamic study of oral oxycodone in a human experimental pain model of hyperalgesia	Olesen, A.; Upton, R.; Foster, D.; Staahl, C.; Christrup, L.; Arendt-Nielsen, L.; Drewes, A.
2005	A physiologically based, recirculatory model of the kinetics and dynamics of propofol in man	Upton, R.; Ludbrook, G.
2002	A quantitative alternative to the hysteresis plot for measurement of drug transit time	Upton, R.; Doolette, D.
2001	Acute cardiovascular effects of magnesium and their relationship to systemic and myocardial magnesium concentrations after short infusion in awake sheep	Zheng, D.; Upton, R.; Ludbrook, G.; Martinez, A.
2003	Acute pain management in the elderly patient	Macintyre, P.; Upton, R.; Ludbrook, G.; Rowbotham, D.; Macintyre, P.
2011	Advances in analgesia in the older patient	Coldrey, J.; Upton, R.; Macintyre, P.
1999	Agreement between ultrasonic Doppler venous outflow and Kety and Schmidt estimates of cerebral blood flow	Doolette, D.; Upton, R.; Grant, C.
2006	Blood-brain distribution of morphine-6-glucuronide in sheep	Villesen, H.; Foster, D.; Upton, R.; Christrup, L.; Somogyi, A.; Martinez, A.; Grant, C.
2006	Blood-brain equilibration kinetics of levo-alpha-acetyl-methadol using a chronically instrumented sheep preparation	Foster, D.; Jensen, M.; Upton, R.; Somogyi, A.; Grant, C.; Martinez, A.
1996	Brain and blood concentrations of propofol after rapid intravenous injection in sheep, and their relationships to cerebral effects	Ludbrook, G.; Upton, R.; Grant, C.; Gray, E.
2005	Brain pharmacokinetics of lignocaine before and following intravenous perfluorocarbon emulsion infusion in sheep	Doolette, D.; Upton, R.; Martinez, A.
2004	Calculating the hybrid (macro) rate constants of a three-compartment mamillary pharmacokinetic model from known micro-rate constants	Upton, R.
1999	Cardiac output is a determinant of the initial concentrations of Propofol after short-infusion administration	Upton, R.; Ludbrook, G.; Grant, C.; Martinez, A.
2001	Cardiovascular and haemodynamic effects of intramuscular doses of xylazine in conscious sheep	Grant, C.; Upton, R.
2003	Cerebral and lung kinetics of morphine in conscious sheep after short intravenous infusions	Upton, R.; Ludbrook, G.; Martinez, A.; Grant, C.; Milne, R.
1996	Cerebral effects of propofol following bolus administration in sheep	Ludbrook, G.; Upton, R.; Grant, C.; Gray, E.
2006	Cerebral kinetics of oxycodone in conscious sheep	Villesen, H.; Foster, D.; Upton, R.; Somogyi, A.; Martinez, A.; Grant, C.
2002	Cerebrovascular carbon dioxide reactivity in sheep: Effect of propofol or isoflurane anaesthesia	Myburgh, J.; Upton, R.; Ludbrook, G.; Martinez, A.; Grant, C.

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