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Type: Journal article
Title: Hypertension and atrial fibrillation: Evidence of progressive atrial remodeling with electrostructural correlate in a conscious chronically instrumented ovine model
Author: Lau, D.
Mackenzie, L.
Kelly, D.
Psaltis, P.
Brooks, A.
Worthington, M.
Rajendram, A.
Kelly, D.
Zhang, Y.
Kuklik, P.
Nelson, A.
Wong, C.
Worthley, S.
Rao, M.
Faull, R.
Edwards, J.
Saint, D.
Sanders, P.
Citation: Heart Rhythm, 2010; 7(9):1282-1290
Publisher: Elsevier Inc.
Issue Date: 2010
ISSN: 1547-5271
Statement of
Dennis H. Lau, Lorraine Mackenzie, Darren J. Kelly, Peter J. Psaltis, Anthony G. Brooks, Michael Worthington, Arumuga Rajendram, Douglas R. Kelly, Yuan Zhang, Pawel Kuklik, Adam J. Nelson, Christopher X. Wong, Stephen G. Worthley, Mohan Rao, Randall J. Faull, James Edwards, David A. Saint, Prashanthan Sanders
Abstract: <h4>Background</h4>Hypertension accounts for more atrial fibrillation (AF) than any other predisposing factor.<h4>Objective</h4>The purpose of this study was to characterize the time course, extent, and electrostructural correlation of atrial remodeling in chronic hypertension.<h4>Methods</h4>Thirty-two sheep were studied: 21 with induced "one-kidney, one-clip" hypertension and 11 controls. Sequential closed-chest electrophysiologic studies were performed in 12 conscious animals (6 hypertensive, 6 controls) to evaluate progressive remodeling over 15 weeks. Additional atrial structural/functional analyses were performed in 5 controls and at 5, 10, and 15 weeks of hypertension (five per time point) via histology/cardiac magnetic resonance imaging to correlate with open-chest electrophysiologic parameters.<h4>Results</h4>The hypertensive group developed a progressive increase in mean arterial pressure (P <.001). Mean effective refractory periods were uniformly higher at all time points (P <.001). Progressive biatrial hypertrophy (P = .003), left atrial dysfunction (P <.05) and greater AF inducibility were seen early with increased inflammation from 5 weeks of hypertension. In contrast, significant conduction slowing (P <.001) with increased heterogeneity (P <.001) along with increased interstitial fibrosis resulted in longer and more fractionated AF episodes only from 10 weeks of hypertension. Significant electrostructural correlation was seen in conduction abnormalities and AF inducibility with both atrial inflammation and fibrosis.<h4>Conclusion</h4>Hypertension is associated with early and progressive changes in atrial remodeling. Atrial remodeling occurs at different time domains in chronic hypertension with significant electrostructural correlation of the remodeling cascade. Early institution of antihypertensive treatment may prevent formation of substrate capable of maintaining AF.
Keywords: Atrial fibrillation
Rights: © 2010 Heart Rhythm Society. All rights reserved.
DOI: 10.1016/j.hrthm.2010.05.010
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