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https://hdl.handle.net/2440/66705
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Type: | Journal article |
Title: | Suspected polymyxin B-induced pemphigus vulgaris in a dog |
Author: | Rybnicek, J. Hill, P. |
Citation: | Veterinary Dermatology: an international journal, 2007; 18(3):165-170 |
Publisher: | Blackwell Science Ltd |
Issue Date: | 2007 |
ISSN: | 0959-4493 1365-3164 |
Statement of Responsibility: | Jan Rybníçek and Peter B. Hill |
Abstract: | A case of pemphigus vulgaris (PV), putatively induced by topical application of polymyxin B ear drops, is described. A 3-year-old, female Tosa Inu, presented with acute onset swelling, blistering and ulceration of the pinnae, nostrils, lips and oral mucous membranes. The dog was depressed, febrile and anorexic. For 7 days prior to the onset of the acute ulcerative disease, polymyxin B ear drops had been applied to both ears to treat an ear infection. Skin and mucosal biopsies showed suprabasilar cleft formation and acantholysis, indicative of PV. The polymyxin B ear drops were discontinued and the dog was treated with intravenous fluids, systemic and topical antibacterial therapy, and immunosuppressive therapy comprising prednisone and azathioprine. Complete remission was noted after 2 weeks, and the immunosuppressive therapy was discontinued one month later. No clinical signs of PV recurred over a 1 year follow-up period. As PV does not usually resolve spontaneously, or enter long-term remission, it was considered that the condition was most likely drug induced due to the aural application of polymyxin B. |
Keywords: | Ear, External Animals Dogs Pemphigus Dog Diseases Polymyxin B Anti-Bacterial Agents Diagnosis, Differential Administration, Cutaneous Female |
Rights: | © 2007 The Authors. |
DOI: | 10.1111/j.1365-3164.2007.00589.x |
Published version: | http://dx.doi.org/10.1111/j.1365-3164.2007.00589.x |
Appears in Collections: | Animal and Veterinary Sciences publications Aurora harvest 5 |
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