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Type: Journal article
Title: Suspected polymyxin B-induced pemphigus vulgaris in a dog
Author: Rybnicek, J.
Hill, P.
Citation: Veterinary Dermatology: an international journal, 2007; 18(3):165-170
Publisher: Blackwell Science Ltd
Issue Date: 2007
ISSN: 0959-4493
Statement of
Jan Rybníçek and Peter B. Hill
Abstract: A case of pemphigus vulgaris (PV), putatively induced by topical application of polymyxin B ear drops, is described. A 3-year-old, female Tosa Inu, presented with acute onset swelling, blistering and ulceration of the pinnae, nostrils, lips and oral mucous membranes. The dog was depressed, febrile and anorexic. For 7 days prior to the onset of the acute ulcerative disease, polymyxin B ear drops had been applied to both ears to treat an ear infection. Skin and mucosal biopsies showed suprabasilar cleft formation and acantholysis, indicative of PV. The polymyxin B ear drops were discontinued and the dog was treated with intravenous fluids, systemic and topical antibacterial therapy, and immunosuppressive therapy comprising prednisone and azathioprine. Complete remission was noted after 2 weeks, and the immunosuppressive therapy was discontinued one month later. No clinical signs of PV recurred over a 1 year follow-up period. As PV does not usually resolve spontaneously, or enter long-term remission, it was considered that the condition was most likely drug induced due to the aural application of polymyxin B.
Keywords: Ear, External
Dog Diseases
Polymyxin B
Anti-Bacterial Agents
Diagnosis, Differential
Administration, Cutaneous
Rights: © 2007 The Authors.
DOI: 10.1111/j.1365-3164.2007.00589.x
Appears in Collections:Animal and Veterinary Sciences publications
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