Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/70615
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Type: Journal article
Title: The impact of obesity on oocytes: evidence for lipotoxicity mechanisms
Author: Linyan Wu, L.
Norman, R.
Robker, R.
Citation: Reproduction Fertility and Development, 2012; 24(1):29-34
Publisher: C S I R O Publishing
Issue Date: 2012
ISSN: 1031-3613
1448-5990
Statement of
Responsibility: 
Linda L.-Y. Wu, Robert J. Norman and Rebecca L. Robker
Abstract: Obesity can have detrimental effects on pregnancy rates in natural conceptions and also in women undergoing IVF or intracytoplasmic sperm injection (ICSI). This review summarises the most recent clinical literature investigating whether obesity impacts oocyte quality and early embryo growth. In other tissues, obesity leads to lipotoxicity responses including endoplasmic reticulum stress, mitochondrial dysfunction and apoptosis. Recent reports indicate that lipotoxicity is a mechanism by which obesity may impact oocyte quality.
Keywords: Endoplasmic reticulum stress; palmitate
Rights: © CSIRO 2012
RMID: 0020115516
DOI: 10.1071/RD11904
Appears in Collections:Obstetrics and Gynaecology publications

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