Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||The impact of obesity on oocytes: evidence for lipotoxicity mechanisms|
|Author:||Linyan Wu, L.|
|Citation:||Reproduction Fertility and Development, 2012; 24(1):29-34|
|Publisher:||C S I R O Publishing|
|Linda L.-Y. Wu, Robert J. Norman and Rebecca L. Robker|
|Abstract:||Obesity can have detrimental effects on pregnancy rates in natural conceptions and also in women undergoing IVF or intracytoplasmic sperm injection (ICSI). This review summarises the most recent clinical literature investigating whether obesity impacts oocyte quality and early embryo growth. In other tissues, obesity leads to lipotoxicity responses including endoplasmic reticulum stress, mitochondrial dysfunction and apoptosis. Recent reports indicate that lipotoxicity is a mechanism by which obesity may impact oocyte quality.|
|Keywords:||Endoplasmic reticulum stress; palmitate|
|Rights:||© CSIRO 2012|
|Appears in Collections:||Obstetrics and Gynaecology publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.