The impact of obesity on oocytes: evidence for lipotoxicity mechanisms
Date
2012
Authors
Linyan Wu, L.
Norman, R.
Robker, R.
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Journal article
Citation
Reproduction, Fertility and Development, 2012; 24(1):29-34
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Linda L.-Y. Wu, Robert J. Norman and Rebecca L. Robker
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DOI
Abstract
Obesity can have detrimental effects on pregnancy rates in natural conceptions and also in women undergoing IVF or intracytoplasmic sperm injection (ICSI). This review summarises the most recent clinical literature investigating whether obesity impacts oocyte quality and early embryo growth. In other tissues, obesity leads to lipotoxicity responses including endoplasmic reticulum stress, mitochondrial dysfunction and apoptosis. Recent reports indicate that lipotoxicity is a mechanism by which obesity may impact oocyte quality.
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© CSIRO 2012