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Type: Journal article
Title: Characterization of copine VII, a new member of the copine family, and its exclusion as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3
Author: Savino, M.
d'Apolito, M.
Centra, M.
van Beerendonk, H.
Cleton-Jansen, A.M.
Whitmore, S.
Crawford, J.
Callen, D.
Zelante, L.
Savoia, A.
Citation: Genomics, 1999; 61(2):219-226
Issue Date: 1999
ISSN: 0888-7543
Statement of
Maria Savino, Maria d'Apolito, Marta Centra, Hetty M. van Beerendonk, Anne-Marie Cleton-Jansen, Scott A. Whitmore, Joanna Crawford, David F. Callen, Leopoldo Zelante and Anna Savoia
Abstract: In a search for candidate tumor suppressor genes within a 650-kb common region of loss of heterozygosity (LOH) at 16q24.3 in breast cancer tissues, a 2.6-kb cDNA, named copine VII (CPNE7), was characterized. The gene is 2654 bp and codes for a 633-residue protein with high homology to the other members of the copine family, such as copine I, copine III, and N-copine. The predicted amino acid sequence contains two copies of a C2 domain in the N-terminus. Since these domains have been found in several membrane-binding proteins involved in different intracellular processes, copine VII was viewed as a potential tumor suppressor gene. Mutation analysis was carried out by single-strand conformation polymorphism analysis of 18 breast tumor tissue samples with ascertained LOH on chromosome 16q24.3. Since only two polymorphisms were identified, no evidence was found to indicate that copine VII is the tumor suppressor gene at 16q24.3 involved in breast cancer.
Keywords: Chromosomes, Human, Pair 16
Breast Neoplasms
Membrane Proteins
Sequence Alignment
DNA Mutational Analysis
Amino Acid Sequence
Base Sequence
Loss of Heterozygosity
Polymorphism, Single-Stranded Conformational
Genes, Tumor Suppressor
Molecular Sequence Data
Description: Copyright © 1999 Academic Press
DOI: 10.1006/geno.1999.5958
Appears in Collections:Aurora harvest
Paediatrics publications

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