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Type: Journal article
Title: A 25-year longitudinal evaluation of gastric emptying in diabetes
Author: Chang, J.
Russo, A.
Bound, M.
Rayner, C.
Jones, K.
Horowitz, M.
Citation: Diabetes Care, 2012; 2012(12):1-3
Publisher: Amer Diabetes Assoc
Issue Date: 2012
ISSN: 0149-5992
Statement of
Jessica Chang, Antonietta Russo, Michelle Bound, Christopher K. Rayner, Karen L. Jones and Michael Horowitz
Abstract: OBJECTIVE: To evaluate the natural history of gastric emptying in diabetes. RESEARCH DESIGN AND METHODS: Thirteen patients with diabetes (12, type 1; 1, type 2) had measurements of gastric emptying, blood glucose levels, glycated hemoglobin, upper gastrointestinal symptoms, and autonomic nerve function at baseline and after 24.7 ± 1.5 years. RESULTS: There was no change in gastric emptying of either solids (% retention at 100 min) (baseline 58.5 ± 5% vs. follow-up 51.9 ± 8%; P = 0.35) or liquids (50% emptying time) (baseline 29.8 ± 3 min vs. follow-up 34.3 ± 6 min; P = 0.37). Gastric emptying of solid at follow-up was related to emptying at baseline (r = 0.56, P < 0.05). At follow-up, blood glucose concentrations were lower (P = 0.006), autonomic function deteriorated (P = 0.03), and gastrointestinal symptoms remained unchanged (P = 0.17). CONCLUSIONS: In unselected patients with diabetes, gastric emptying appears remarkably stable over 25 years.
Keywords: Humans
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Longitudinal Studies
Gastric Emptying
Middle Aged
Glycated Hemoglobin
Rights: © 2012 by the American Diabetes Association
DOI: 10.2337/dc12-0028
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