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https://hdl.handle.net/2440/73423
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Type: | Journal article |
Title: | A 25-year longitudinal evaluation of gastric emptying in diabetes |
Author: | Chang, J. Russo, A. Bound, M. Rayner, C. Jones, K. Horowitz, M. |
Citation: | Diabetes Care, 2012; 2012(12):1-3 |
Publisher: | Amer Diabetes Assoc |
Issue Date: | 2012 |
ISSN: | 0149-5992 1935-5548 |
Statement of Responsibility: | Jessica Chang, Antonietta Russo, Michelle Bound, Christopher K. Rayner, Karen L. Jones and Michael Horowitz |
Abstract: | OBJECTIVE: To evaluate the natural history of gastric emptying in diabetes. RESEARCH DESIGN AND METHODS: Thirteen patients with diabetes (12, type 1; 1, type 2) had measurements of gastric emptying, blood glucose levels, glycated hemoglobin, upper gastrointestinal symptoms, and autonomic nerve function at baseline and after 24.7 ± 1.5 years. RESULTS: There was no change in gastric emptying of either solids (% retention at 100 min) (baseline 58.5 ± 5% vs. follow-up 51.9 ± 8%; P = 0.35) or liquids (50% emptying time) (baseline 29.8 ± 3 min vs. follow-up 34.3 ± 6 min; P = 0.37). Gastric emptying of solid at follow-up was related to emptying at baseline (r = 0.56, P < 0.05). At follow-up, blood glucose concentrations were lower (P = 0.006), autonomic function deteriorated (P = 0.03), and gastrointestinal symptoms remained unchanged (P = 0.17). CONCLUSIONS: In unselected patients with diabetes, gastric emptying appears remarkably stable over 25 years. |
Keywords: | Humans Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Longitudinal Studies Gastric Emptying Aged Middle Aged Female Male Glycated Hemoglobin |
Rights: | © 2012 by the American Diabetes Association |
DOI: | 10.2337/dc12-0028 |
Published version: | http://dx.doi.org/10.2337/dc12-0028 |
Appears in Collections: | Aurora harvest Medicine publications |
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