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https://hdl.handle.net/2440/73922
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Type: | Journal article |
Title: | Structural approaches to probing metal interaction with proteins |
Author: | Parker, L. Ascher, D. Chen, G. Miles, L. Harris, H. Parker, M. |
Citation: | Journal of Inorganic Biochemistry, 2012; 115:138-147 |
Publisher: | Elsevier Science Inc |
Issue Date: | 2012 |
ISSN: | 0162-0134 1873-3344 |
Statement of Responsibility: | Lorien J. Parker, David B. Ascher, Chen Gao, Luke A. Miles, Hugh H. Harris, Michael W. Parker |
Abstract: | In this mini-review we focus on metal interactions with proteins with a particular emphasis on the evident synergism between different biophysical approaches toward understanding metallobiology. We highlight three recent examples from our own laboratory. Firstly, we describe metallodrug interactions with glutathione S-transferases, an enzyme family known to attack commonly used anti-cancer drugs. We then describe a protein target for memory enhancing drugs called insulin-regulated aminopeptidase in which zinc plays a role in catalysis and regulation. Finally we describe our studies on a protein, amyloid precursor protein, that appears to play a central role in Alzheimer's disease. Copper ions have been implicated in playing both beneficial and detrimental roles in the disease by binding to different regions of this protein. |
Keywords: | Amyloid precursor protein Glutathione transferase Insulin-regulated aminopeptidase X-ray absorption spectroscopy X-ray crystallography |
Rights: | Copyright © 2012 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.jinorgbio.2012.02.015 |
Published version: | http://dx.doi.org/10.1016/j.jinorgbio.2012.02.015 |
Appears in Collections: | Aurora harvest 4 Chemistry publications Environment Institute publications IPAS publications |
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