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https://hdl.handle.net/2440/7427
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Type: | Journal article |
Title: | Multicentre evaluation of the in vitro activity of linezolid in the Western Pacific |
Author: | Bell, J. Turnidge, J. Ballow, C. Jones, R. |
Citation: | Journal of Antimicrobial Chemotherapy, 2003; 51(2):339-345 |
Publisher: | Oxford Univ Press |
Issue Date: | 2003 |
ISSN: | 0305-7453 1460-2091 |
Statement of Responsibility: | Bell, Jan M; Turnidge, John D; Ballow, Charles H; Jones, Ronald N |
Abstract: | Multiresistance to antimicrobial agents is common in staphylococci and pneumococci isolates in the Western Pacific region. The activity of linezolid, a new oxazolidinone, was evaluated against a spectrum of Gram-positive species collected in the region. Eighteen laboratories from six countries in the Western Pacific examined the linezolid susceptibility of 2143 clinical isolates of Staphylococcus aureus, coagulase-negative staphylococci (CoNS) and Enterococcus spp. using broth microdilution or disc diffusion methodology. For Streptococcus pneumoniae (n = 351) and other streptococci (n = 83), Etest (AB Biodisk, Solna, Sweden) strips were used. Results were compared with other common and important antimicrobials. Linezolid-resistant strains were not detected among streptococci or staphylococci, including a significant proportion of S. aureus strains that were multiresistant. Almost all enterococci, including 14 vancomycin-resistant Enterococcus faecium, were linezolid susceptible. A small proportion of enterococci (0.8%) were intermediate to linezolid, and one strain of Enterococcus faecalis had a zone diameter of 20 mm (resistant). The linezolid MIC ranges (MIC(90)) of those strains tested by broth microdilution or Etest were: 1-4 mg/L (2 mg/L) for S. aureus, 0.5-4 mg/L (2 mg/L) for CoNS, 0.5-4 mg/L (2 mg/L) for Enterococcus spp., 0.12-2 mg/L (1 mg/L) for S. pneumoniae and 0.25-2 mg/L (1 mg/L) for Streptococcus spp. There was no difference in linezolid susceptibility between countries or between multiresistant and susceptible strains of each species monitored. |
Keywords: | ZAPS Regional Participants Gram-Positive Bacteria Enterococcus faecalis Enterococcus faecium Streptococcus pneumoniae Gram-Positive Bacterial Infections Acetamides Oxazolidinones Anti-Bacterial Agents Microbial Sensitivity Tests Data Collection Drug Resistance, Bacterial Australia Linezolid Asia, Eastern |
DOI: | 10.1093/jac/dkg074 |
Published version: | http://dx.doi.org/10.1093/jac/dkg074 |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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