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|Title:||Mechanism of gastroesophageal reflux in premature infants with chronic lung disease|
|Citation:||Journal of Pediatric Surgery, 1999; 34(12):1795-1798|
|Publisher:||W B SAUNDERS CO-ELSEVIER INC|
|T. Omari, C. Barnett, A. Snel, G. Davidson, R. Haslam, M. Bakewell, and J. Dent|
|Abstract:||BACKGROUND/PURPOSE:The aim of this study was to characterize the motor events responsible for gastroesophageal reflux (GER) and esophageal acid clearance in a cohort of preterm infants with chronic lung disease (CLD). METHODS:Esophageal motility was recorded for 2 to 3 hours postprandially in 14 preterm infants with mild-moderate or moderate-severe CLD at 33 to 39 weeks postmenstrual age using a sleeve-side hole micromanometric assembly into which a pH probe had been installed. RESULTS:Twenty-six acid GER episodes were recorded by pH probe. Of these, 22 (85%) were associated with transient lower esophageal sphincter (LES) relaxation. Transient LES relaxations were significantly longer in duration than single swallows (13.7 seconds v 4.6 seconds, P < .001) and had lower nadir pressures (1.1 mm Hg v 2.5 mm Hg, P < .001). During periods of esophageal acidification (pH below 4), peristaltic esophageal body pressure wave sequences cleared acid refluxate more effectively than nonperistaltic pressure wave sequences. CONCLUSIONS:In preterm infants with CLD, transient LES relaxations are the predominant mechanism underlying GER, and esophageal clearance mechanisms are fully functional, which is similar to that seen in healthy preterm infants.|
|Keywords:||Chronic lung disease|
acid gastroesophageal reflux
esophageal acid clearance
transient lower esophageal sphincter relaxation.
|Rights:||Copyright © 1999 Published by Elsevier Inc.|
|Appears in Collections:||Aurora harvest|
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