Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/76996
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Type: Journal article
Title: Epigenetic biomarkers in prostate cancer: current and future uses
Author: Chiam, K.
Ricciardelli, C.
Bianco-Miotto, T.
Citation: Cancer Letters, 2014; 342(2):248-256
Publisher: Elsevier Sci Ireland Ltd
Issue Date: 2014
ISSN: 0304-3835
1872-7980
Statement of
Responsibility: 
Karen Chiam, Carmela Ricciardelli and Tina Bianco-Miotto
Abstract: Epigenome alterations are characteristic of nearly all human malignancies and include changes in DNA methylation, histone modifications and microRNAs (miRNAs). However, what induces these epigenetic alterations in cancer is largely unknown and their mechanistic role in prostate tumorigenesis is just beginning to be evaluated. Identification of the epigenetic modifications involved in the development and progression of prostate cancer will not only identify novel therapeutic targets but also prognostic and diagnostic markers. This review will focus on the use of epigenetic modifications as biomarkers for prostate cancer.
Keywords: Animals; Humans; Prostatic Neoplasms; Genetic Predisposition to Disease; Histones; MicroRNAs; Tumor Markers, Biological; Prognosis; Predictive Value of Tests; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Phenotype; Male; Genetic Testing
Rights: © 2012 Elsevier Ireland Ltd. All rights reserved.
RMID: 0020126190
DOI: 10.1016/j.canlet.2012.02.011
Appears in Collections:Obstetrics and Gynaecology publications

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