Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/76996
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Epigenetic biomarkers in prostate cancer: current and future uses |
Author: | Chiam, K. Ricciardelli, C. Bianco-Miotto, T. |
Citation: | Cancer Letters, 2014; 342(2):248-256 |
Publisher: | Elsevier Sci Ireland Ltd |
Issue Date: | 2014 |
ISSN: | 0304-3835 1872-7980 |
Statement of Responsibility: | Karen Chiam, Carmela Ricciardelli and Tina Bianco-Miotto |
Abstract: | Epigenome alterations are characteristic of nearly all human malignancies and include changes in DNA methylation, histone modifications and microRNAs (miRNAs). However, what induces these epigenetic alterations in cancer is largely unknown and their mechanistic role in prostate tumorigenesis is just beginning to be evaluated. Identification of the epigenetic modifications involved in the development and progression of prostate cancer will not only identify novel therapeutic targets but also prognostic and diagnostic markers. This review will focus on the use of epigenetic modifications as biomarkers for prostate cancer. |
Keywords: | Animals Humans Prostatic Neoplasms Genetic Predisposition to Disease Histones MicroRNAs Prognosis Predictive Value of Tests DNA Methylation Epigenesis, Genetic Gene Expression Regulation, Neoplastic Phenotype Male Genetic Testing Biomarkers, Tumor |
Rights: | © 2012 Elsevier Ireland Ltd. All rights reserved. |
DOI: | 10.1016/j.canlet.2012.02.011 |
Published version: | http://dx.doi.org/10.1016/j.canlet.2012.02.011 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.