Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/7802
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Type: Journal article
Title: Expression of cytokine receptors by human cord blood lymphocytes: comparison with adult blood lymphocytes
Author: Zola, H.
Fusco, M.
Macardle, P.
Flego, L.
Roberton, D.
Citation: Pediatric Research, 1995; 38(3):397-403
Publisher: S. Karger
Issue Date: 1995
ISSN: 0031-3998
1530-0447
Abstract: The expression of receptors for several cytokines (IL 2, IL-4, IL-6, IL-7, tumor necrosis factor, and interferon-gamma) was examined in human cord blood cells in comparison with adult blood cells. A previously described high sensitivity immunofluorescence procedure was used to render the low levels of receptor measurable. Cord blood lymphocytes expressed measurable levels of most cytokine receptors, but expression tended to be lower than in adult blood cells. Examination of different lymphocyte subpopulations revealed a complex pattern with some cell types expressing particular receptors equivalent to adult levels. Cord and adult blood monocytes expressed similar cytokine receptor profiles. Receptor expression in cord lymphocytes could be regulated by activation. The results provide indications as to the relative activities of different cytokines in the development of the immune system in the neonate.
Keywords: Lymphocytes; Monocytes; Cells, Cultured; Fetal Blood; Humans; Phytohemagglutinins; Receptors, Cytokine; Interleukin-4; Antibodies, Monoclonal; Flow Cytometry; Lymphocyte Activation; Adult; Infant, Newborn
RMID: 0030005401
DOI: 10.1203/00006450-199509000-00021
Appears in Collections:Paediatrics publications

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