Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/80204
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Type: Journal article
Title: Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans
Author: Brotherton, P.
Haak, W.
Templeton, J.
Soubrier, J.
Adler, C.
Richards, S.
Dersarkissian, C.
Cooper, A.
Citation: Nature Communications, 2013; 4(1764):1-11
Publisher: Nature Publishing Group
Issue Date: 2013
ISSN: 2041-1723
2041-1723
Statement of
Responsibility: 
Paul Brotherton, Wolfgang Haak, Jennifer Templeton, Guido Brandt, Julien Soubrier, Christina Jane Adler, Stephen M. Richards, Clio Der Sarkissian, Robert Ganslmeier, Susanne Friederich, Veit Dresely, Mannis van Oven, Rosalie Kenyon, Mark B. Van der Hoek, Jonas Korlach, Khai Luong, Simon Y.W. Ho, Lluis Quintana-Murci, Doron M. Behar, Harald Meller, Kurt W. Alt, Alan Cooper & The Genographic Consortium
Abstract: Haplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (~19%) among Early Neolithic farmers (~5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this 'real-time' genetic data with cultural changes taking place between the Early Neolithic (~5450 BC) and Bronze Age (~2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (~4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (~2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45% higher than current estimates for human mitochondria.
Keywords: Genographic Consortium; Humans; Sequence Analysis, DNA; Genetics, Population; Demography; Evolution, Molecular; Phylogeny; Base Sequence; Haplotypes; Genome, Human; Principal Component Analysis; Time Factors; Molecular Sequence Data; European Continental Ancestry Group; Genome, Mitochondrial
Rights: © 2013 Macmillan Publishers Limited. All rights reserved
RMID: 0020127464
DOI: 10.1038/ncomms2656
Grant ID: http://purl.org/au-research/grants/arc/LP0882622
Appears in Collections:Australian Centre for Ancient DNA publications

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