Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/8564
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Type: Journal article
Title: Involvement of cholecystokinin A receptors in transient lower esophageal sphincter relaxations triggered by gastric distension
Author: Boeckxstaens, G.
Hirsch, D.
Fakhry, N.
Holloway, R.
D'Amato, M.
Tytgat, G.
Citation: American Journal of Gastroenterology, 1998; 93(10):1823-
Publisher: ELSEVIER SCIENCE INC
Issue Date: 1998
ISSN: 0002-9270
1572-0241
Statement of
Responsibility: 
G. E. Boeckxstaens, D. P. Hirsch, N. Fakhry, R. H. Holloway, M. D’Amato, and G. N. J. Tytgat,
Abstract: <h4>Objective</h4>Transient lower esophageal sphincter relaxations (TLESRs) are the main mechanism underlying gastroesophageal reflux. In the present study we evaluated the effect of loxiglumide, a specific cholecystokininA (CCKA)-receptor antagonist, on the occurrence of TLESRs evoked by gastric distension.<h4>Methods</h4>Eight healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide (10 mg/kg/h) in a randomized double-blind order. Gastric distension was induced by inflation of 400 ml of air.<h4>Results</h4>Basal lower esophageal pressure (LESP) and swallow-induced relaxation were not affected by loxiglumide. Loxiglumide significantly reduced the number of TLESRs, from 11.5 (5.8-18.3) to 6.0 (3.3-14.3) during the total recording period of 1 h, and from 5.5 (4.25-7.5) to 2.0 (0.5-6.8) during the first 15 min. The number of common cavities was significantly decreased by loxiglumide, from 8.0 (4.0-20.0) to 5.0 (2.0-7.8). TLESRs represented the main mechanism (60% during placebo, 74% during loxiglumide) underlying common cavities, followed by swallow-induced relaxation.<h4>Conclusions</h4>Loxiglumide significantly reduces the number of TLESRs triggered by gastric distension without interfering with swallow-related relaxation of the lower esophageal sphincter, suggesting the involvement of CCKA receptors in the reflex pathway mediating TLESRs.
Keywords: Esophagogastric Junction
Stomach
Humans
Gastroesophageal Reflux
Hormone Antagonists
Proglumide
Receptors, Cholecystokinin
Receptor, Cholecystokinin A
Reflex
Double-Blind Method
Manometry
Deglutition
Peristalsis
Adult
Female
Male
DOI: 10.1016/S0002-9270(98)00408-0
Appears in Collections:Aurora harvest
Medicine publications

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