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Type: Journal article
Title: Effect of nitric oxide synthase inhibitors on short-term appetite and food intake in humans
Author: Vozzo, R.
Wittert, G.
Horowitz, M.
Morley, J.
Chapman, I.
Citation: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 1999; 276(6):R1562-R1568
Publisher: American Physiological Society
Issue Date: 1999
ISSN: 0363-6119
Statement of
Rosalie Vozzo, Gary A. Wittert, Michael Horowitz, John E. Morley, and Ian M. Chapman
Abstract: Animal studies suggest that nitric oxide (NO) may be a physiological regulator of appetite; NO synthase (NOS) inhibition suppresses food intake in rats, mice, and chickens. It is not known whether NO has any effect on appetite in humans. We have usedN G-monomethyl-l-arginine (l-NMMA) andN G-nitro-l-arginine methyl ester (l-NAME), both competitive, nonselective inhibitors of NOS, in two separate studies to evaluate the role of NO in the short-term regulation of appetite in humans. Instudy I, 13 men (18–25 yr) underwent paired studies, in randomized, double-blind fashion, after an overnight fast. l-NMMA (4 mg ⋅ kg−1 ⋅ h−1) or saline (0.9%) was infused intravenously at a rate of 40 ml/h for 1.5 h. In study II, eight men (18–26 yr) underwent three randomized, double-blind studies after an overnight fast. l-NAME (75 or 180 μg ⋅ kg−1 ⋅ h−1) or saline (0.9%) was infused intravenously at a rate of 20 ml/h for 120 min. Hunger and fullness were measured using visual analog scales; blood pressure and heart rate were monitored, and 30 min before the end of the infusion, subjects were offered a cold buffet meal. Total caloric intake and the macronutrient composition of the meal were determined. Both l-NMMA (P = 0.052) andl-NAME (P < 0.05; both doses) decreased heart rate, l-NMMA increased diastolic blood pressure (P < 0.01), and l-NAME increased systolic blood pressure (P = 0.052). Neither drug had any effect on caloric intake or sensations of hunger or fullness. Despite having significant effects on cardiovascular function in the doses used, neitherl-NMMA norl-NAME had any effect on feeding, suggesting that NO does not affect short-term appetite or food intake in humans.
Keywords: Humans
NG-Nitroarginine Methyl Ester
Enzyme Inhibitors
Double-Blind Method
Satiety Response
Blood Pressure
Heart Rate
Nitric Oxide Synthase
Rights: Copyright © 1999 the American Physiological Society
DOI: 10.1152/ajpregu.1999.276.6.r1562
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