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https://hdl.handle.net/2440/86214
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Type: | Journal article |
Title: | Start of induction of labour with oxytocin in the morning or in the evening. A randomised controlled trial |
Author: | Bakker, J. De Vos, R. Pel, M. Wisman, C. van Lith, J. Mol, B. van der Post, J. |
Citation: | BJOG: an International Journal of Obstetrics and Gynaecology, 2009; 116(4):562-568 |
Publisher: | Wiley |
Issue Date: | 2009 |
ISSN: | 1470-0328 1471-0528 |
Statement of Responsibility: | JJ Bakker, R De Vos, M Pel, C Wisman, JM Van Lith, BWJ Mol, JA Van Der Post |
Abstract: | Objective: The objective of this study was to compare outcomes of induced labour with intravenous oxytocin with a start in the evening versus in the morning. Design: Randomised controlled trial. Setting: Labour wards of three hospitals in Amsterdam, the Netherlands. Participants: Women with an indication for induction of labour with intravenous oxytocin. Methods: Included women were randomized to either the evening group with a start of induction of labour at 21:00 hours, or the morning group with a start at 07:00 hours. Main outcome measures: Primary outcome was duration of labour. Secondary outcomes were instrumental delivery rate, adverse neonatal outcome defined as an Apgar score below 7 after 5 minutes, number and indications of paediatric consults and neonatal admissions, duration of second stage, number of intrapartum infections and necessity of pain relief. Results: We randomised 371 women. Mean duration of labour was not significantly different (primiparae: morning 12 hours and 8 minutes versus evening 11 hours and 22 minutes, P value 0.29; multiparae: morning 7 hours and 34 minutes versus evening 7 hours and 46 minutes, P value 0.70). There were no significant differences in instrumental deliveries rates, number of infections or patient satisfaction. Unexpectedly, neonatal outcome was better in women induced in the evening. Conclusion: Induction of labour with intravenous oxytocin in the evening is equally effective as induction in the morning. |
Keywords: | Circadian rhythm; duration of labour; induced labour; oxytocin |
Description: | Article first published online: 18 FEB 2009 |
Rights: | © 2009 The Authors |
DOI: | 10.1111/j.1471-0528.2008.02102.x |
Published version: | http://dx.doi.org/10.1111/j.1471-0528.2008.02102.x |
Appears in Collections: | Aurora harvest 7 Obstetrics and Gynaecology publications |
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