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https://hdl.handle.net/2440/8834
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Type: | Journal article |
Title: | Changes in blood glucose within the physiological range affect gastric emptying in normal subjects and patients with insulin dependent diabetes mellitus |
Author: | Schvarcz, E. Palmer, M. Aman, J. Horowitz, M. Stridsberg, M. Berne, C. |
Citation: | Gastroenterology, 1997; 113(1):60-66 |
Publisher: | W B SAUNDERS CO |
Issue Date: | 1997 |
ISSN: | 0016-5085 1528-0012 |
Abstract: | <h4>Background & aims</h4>Marked hyperglycemia slows and hypoglycemia accelerates gastric emptying. The aim of this study was to determine the effect of physiological changes in blood glucose gastric emptying.<h4>Methods</h4>In 8 healthy subjects and 9 patients with insulin-dependent diabetes mellitus (IDDM) without gastrointestinal tract symptoms or evidence of neuropathy, gastric emptying of a mixed meal was measured by scintigraphy. Using an insulin-glucose clamp, the blood glucose concentration was stabilized at 4 and 8 mmol/L on 2 separate days.<h4>Results</h4>The intragastric retention of the solid meal component at 100 minutes was 55.2% +/- 4.5% at 8 mmol/L vs. 36.7% +/- 5.5% at 4 mmol/L (P = 0.004) in normal subjects and 44.2% +/- 4.2% vs. 35.7% +/- 4.2% (P = 0.004) in patients with IDDM. The time taken for 50% emptying of the liquid meal was 57.0 +/- 10.8 minutes at 8 mmol/L vs. 32.2 +/- 12.6 minutes at 4 mmol/L (P = 0.002) in normal subjects and 41.3 +/- 3.4 minutes vs. 29.1 +/- 3.5 minutes (P = 0.002) in patients with IDDM.<h4>Conclusions</h4>Changes in blood glucose within the normal postprandial range have a significant impact on gastric emptying in both normal subjects and patients with IDDM. |
Keywords: | Stomach Humans Diabetes Mellitus, Type 1 Technetium Tc 99m Aggregated Albumin Blood Glucose Radionuclide Imaging Glucose Clamp Technique Case-Control Studies Gastric Emptying Time Factors Adult Male |
DOI: | 10.1016/S0016-5085(97)70080-5 |
Published version: | http://dx.doi.org/10.1016/s0016-5085(97)70080-5 |
Appears in Collections: | Aurora harvest Medicine publications |
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