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Type: Journal article
Title: Effect of the motilin agonist KC 11458 on gastric emptying in diabetic gastroparesis
Author: Russo, A.
Stevens, J.
Giles, N.
Krause, G.
O'Donovan, D.
Horowitz, M.
Jones, K.
Citation: Alimentary Pharmacology and Therapeutics, 2004; 20(3):333-338
Publisher: Blackwell Publishing Ltd
Issue Date: 2004
ISSN: 0269-2813
Statement of
A. Russo, J. E. Stevens, N. Giles, G. Krause, D. G. O’Donovan, M. Horowitz & K. L. Jones
Abstract: Background: KC 11458, a motilin agonist without antibiotic properties, accelerates gastric emptying in animals and healthy humans. Aim: To evaluate the acute effects of KC 11458 on gastric emptying in diabetic gastroparesis. Methods: Twenty-nine patients (6 type 1 and 23 type 2) with gastroparesis underwent assessments of: (i) gastric emptying of a solid/liquid meal using scintigraphy, (ii) glycaemic control (blood glucose at 0, 30, 60, 90 and 120 min during the gastric emptying measurement) and (iii) upper gastrointestinal and ‘meal-related’ symptoms (questionnaire), at baseline and after treatment with KC 11458 in a dose of 8 mg t.d.s., or placebo for 8 days. Results: KC 11458 had no statistically significant or clinically relevant effect on gastric emptying of either the solid intragastric retention at 100 min (T100) (P ¼ 0.87) or liquid 50% emptying time (T50) (P ¼ 0.17) components of the meal. KC 11458 slightly worsened (P ¼ 0.04) upper gastrointestinal symptoms when compared with placebo. The magnitude of the change in solid gastric emptying correlated with the change in the blood glucose concentration (r ¼ 0.49; P < 0.05). Conclusions: KC 11458, in a dose of 8 mg t.d.s. for 8 days, does not accelerate gastric emptying in patients with diabetic gastroparesis. The absence of efficacy may relate to an effect of hyperglycaemia.
Keywords: Humans
Autonomic Nervous System Diseases
Diabetic Neuropathies
Diabetes Mellitus
Blood Glucose
Gastric Emptying
Middle Aged
Description: The definitive version is available at Article first published online: 9 JUL 2004
Rights: © 2004 Blackwell Publishing Ltd
DOI: 10.1111/j.1365-2036.2004.02066.x
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