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Type: Journal article
Title: Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) acts as a regulator of B-cell development, B-cell antigen receptor (BCR)-mediated activation, and autoimmune disease
Author: Wilkinson, R.
Lyons, A.
Roberts, D.
Wong, M.
Bartley, P.
Jackson, D.
Citation: Blood, 2002; 100(1):184-193
Publisher: Amer Soc Hematology
Issue Date: 2002
ISSN: 0006-4971
Statement of
Ray Wilkinson, A. Bruce Lyons, Donna Roberts, Mae-Xhum Wong, Paul A. Bartley, and Denise E. Jackson
Abstract: Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) is an immunoglobulin-immunoreceptor tyrosine-based inhibitory motif (Ig-ITIM) superfamily member that recruits and activates protein-tyrosine phosphatases, SHP-1 and SHP-2, through its intrinsic ITIMs. PECAM-1-deficient (PECAM-1(-/-) ) mice exhibit a hyperresponsive B-cell phenotype, increased numbers of B-1 cells, reduced B-2 cells, and develop autoantibodies. In the periphery, there are reduced mature recirculating B-2 cells and increased B-1a cells within the peritoneal cavity. In addition, PECAM-1(-/-) B cells display hyperproliferative responses to lipopolysaccharide and anti-IgM stimulation and showed enhanced kinetics in their intracellular Ca(++) response following IgM cross-linking. PECAM-1(-/-) mice showed increased serum levels of IgM with elevated IgG isotypes and IgA antidinitrophenol antibody in response to the T-independent antigen, dinitrophenol-Ficoll. Finally, PECAM-1(-/-) mice developed antinuclear antibodies and lupuslike autoimmune disease with age.
Keywords: B-Lymphocytes
Bone Marrow
Mice, Knockout
Autoimmune Diseases
Receptors, Antigen, B-Cell
Lymphocyte Activation
Calcium Signaling
Antibody Formation
Platelet Endothelial Cell Adhesion Molecule-1
Description: Copyright © 2002 by The American Society of Hematology.
DOI: 10.1182/blood-2002-01-0027
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Appears in Collections:Aurora harvest
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