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https://hdl.handle.net/2440/9305
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Type: | Journal article |
Title: | Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) acts as a regulator of B-cell development, B-cell antigen receptor (BCR)-mediated activation, and autoimmune disease |
Author: | Wilkinson, R. Lyons, A. Roberts, D. Wong, M. Bartley, P. Jackson, D. |
Citation: | Blood, 2002; 100(1):184-193 |
Publisher: | Amer Soc Hematology |
Issue Date: | 2002 |
ISSN: | 0006-4971 1528-0020 |
Statement of Responsibility: | Ray Wilkinson, A. Bruce Lyons, Donna Roberts, Mae-Xhum Wong, Paul A. Bartley, and Denise E. Jackson |
Abstract: | Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) is an immunoglobulin-immunoreceptor tyrosine-based inhibitory motif (Ig-ITIM) superfamily member that recruits and activates protein-tyrosine phosphatases, SHP-1 and SHP-2, through its intrinsic ITIMs. PECAM-1-deficient (PECAM-1(-/-) ) mice exhibit a hyperresponsive B-cell phenotype, increased numbers of B-1 cells, reduced B-2 cells, and develop autoantibodies. In the periphery, there are reduced mature recirculating B-2 cells and increased B-1a cells within the peritoneal cavity. In addition, PECAM-1(-/-) B cells display hyperproliferative responses to lipopolysaccharide and anti-IgM stimulation and showed enhanced kinetics in their intracellular Ca(++) response following IgM cross-linking. PECAM-1(-/-) mice showed increased serum levels of IgM with elevated IgG isotypes and IgA antidinitrophenol antibody in response to the T-independent antigen, dinitrophenol-Ficoll. Finally, PECAM-1(-/-) mice developed antinuclear antibodies and lupuslike autoimmune disease with age. |
Keywords: | B-Lymphocytes Bone Marrow Animals Mice, Knockout Mice Autoimmune Diseases Receptors, Antigen, B-Cell Autoantibodies Lymphocyte Activation Apoptosis Calcium Signaling Antibody Formation Platelet Endothelial Cell Adhesion Molecule-1 |
Description: | Copyright © 2002 by The American Society of Hematology. |
DOI: | 10.1182/blood-2002-01-0027 |
Published version: | http://bloodjournal.hematologylibrary.org/cgi/content/abstract/100/1/184 |
Appears in Collections: | Aurora harvest Medicine publications |
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