Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Peripheral natural killer cell and allo-stimulated T-cell function in kidney transplant recipients associate with cancer risk and immunosuppression-related complications|
|Citation:||Kidney International, 2015; 88(6):1374-1382|
|Publisher:||Nature Publishing Group|
|Christopher M Hope, Alexander Troelnikov, William Hanf, Shilpanjali Jesudason, Patrick T Coates, Peter S Heeger, and Robert P Carroll|
|Abstract:||Reducing immunosuppression has been proposed as a means of preventing cancer in kidney transplant recipients but this can precipitate graft rejection. Here we tested whether anti-tumor natural killer (NK) cell and allo-responsive T-cell function in kidney transplant recipients may predict cancer risk and define risk of rejection. NK cell function was measured by the release of lactate dehydrogenase and T-cell allo-response by interferon-γ quantification using a panel of reactive T-cell enzyme-linked immunospot (ELISPOT) in 56 kidney transplant recipients with current or past cancer and 26 kidney transplant recipients without cancer. NK function was significantly impaired and the allo-response was significantly lower in kidney transplant recipients with cancer. With prospective follow-up, kidney transplant recipients with poor NK cell function had a hazard ratio of 2.1 (95% confidence interval 0.97-5.00) for the combined end point of metastatic cancer, cancer-related death, or septic death. Kidney transplant recipients with low interferon-γ release were also more likely to reach this combined end point. Thus, posttransplant monitoring of allo-immunity and NK cell function is useful for assessing the risk of over immunosuppression for the development of malignancy and/or death from cancer or sepsis.|
|Keywords:||cancer; IFN-γ ELISPOT; immunosuppression; kidney transplantation; NK cells|
|Description:||Advance online publication 12 August 2015|
|Rights:||© 2015 International Society of Nephrology|
|Appears in Collections:||Medicine publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.