Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9405
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Type: Journal article
Title: Relationships of upper gastrointestinal motor and sensory function with glycemic control
Author: Rayner, C.
Samsom, M.
Jones, K.
Horowitz, M.
Citation: Diabetes Care, 2001; 24(2):371-381
Publisher: Amer Diabetes Assoc
Issue Date: 2001
ISSN: 0149-5992
1935-5548
Statement of
Responsibility: 
Christopher K. Rayner, Melvin Samsom, Karen L. Jones and Michael Horowitz
Abstract: Acute changes in the blood glucose concentration have a major reversible effect on esophageal, gastric, intestinal, gallbladder, and anorectal motility in both healthy subjects and diabetic patients. For example, gastric emptying is slower during hyperglycemia than euglycemia and accelerated during hypoglycemia. Acute hyperglycemia also affects perceptions arising from the gastrointestinal tract and may, accordingly, be important in the etiology of gastrointestinal symptoms in diabetes. Elevations in blood glucose that are within the normal postprandial range also affect gastrointestinal motor and sensory function. Upper gastrointestinal motor function is a critical determinant of postprandial blood glucose concentrations by influencing the absorption of ingested nutrients. Interventions that reduce postprandial hyperglycemia, by modulating the rate of gastric emptying, have the potential to become mainstream therapies in the treatment of diabetes.
Keywords: Digestive System; Intestine, Small; Esophagus; Stomach; Humans; Diabetes Mellitus; Hyperglycemia; Hypoglycemia; Glucose; Blood Glucose; Sensation; Gastrointestinal Motility; Gastric Emptying
Description: Copyright © 2001 American Diabetes Association
RMID: 0020012034
DOI: 10.2337/diacare.24.2.371
Appears in Collections:Medicine publications

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