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https://hdl.handle.net/2440/96783
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Type: | Journal article |
Title: | Spontaneous glomerular mesangial lesions in common marmoset monkeys (Callithrix jacchus): a benign non-progressive glomerulopathy |
Author: | Collins, M.G. Rogers, N.M. Jesudason, S. Kireta, S. Brealey, J. Coates, P.T. |
Citation: | Journal of Medical Primatology, 2014; 43(6):477-487 |
Publisher: | Wiley |
Issue Date: | 2014 |
ISSN: | 0047-2565 1600-0684 |
Statement of Responsibility: | Michael G. Collins, Natasha M. Rogers, Shilpanjali Jesudason, Svjetlana Kireta, John Brealey and Patrick Toby Coates |
Abstract: | BACKGROUND: Common marmosets are known to develop an IgM glomerulopathy, which has been linked with 'wasting marmoset' syndrome. This study investigated renal pathology in a colony of marmosets, with and without weight loss. METHODS: Renal histology, immunofluorescence, and electron microscopy were performed on marmosets euthanized for research or for weight loss. Serum and urine biochemistry were measured during life and at euthanasia. RESULTS: Histology from 25 adult marmosets (19 research and 6 weight loss) showed mesangial expansion in the majority of glomeruli. Mesangial changes correlated with electron-dense deposits and IgM deposition by immunofluorescence; negligible other pathology was seen. Glomerular basement membrane thickness appeared increased compared to reported human measurements. Low-grade proteinuria was present in all animals, but did not progress. Renal function was normal in all animals. CONCLUSIONS: Marmosets develop a glomerulopathy characterized by mesangial expansion, IgM deposition, and proteinuria. This is a benign occurrence and not specifically associated with weight loss. |
Keywords: | Callitrichidae; glomerular disease; immune complex deposition; mesangium; non-human primates; proteinuria |
Description: | Article first published online: 30 JUN 2014 |
Rights: | © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
DOI: | 10.1111/jmp.12134 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/399374 http://purl.org/au-research/grants/nhmrc/563800 |
Published version: | http://dx.doi.org/10.1111/jmp.12134 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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