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|Title:||Spontaneous glomerular mesangial lesions in common marmoset monkeys (Callithrix jacchus): a benign non-progressive glomerulopathy|
|Citation:||Journal of Medical Primatology, 2014; 43(6):477-487|
|Michael G. Collins, Natasha M. Rogers, Shilpanjali Jesudason, Svjetlana Kireta, John Brealey and Patrick Toby Coates|
|Abstract:||BACKGROUND: Common marmosets are known to develop an IgM glomerulopathy, which has been linked with 'wasting marmoset' syndrome. This study investigated renal pathology in a colony of marmosets, with and without weight loss. METHODS: Renal histology, immunofluorescence, and electron microscopy were performed on marmosets euthanized for research or for weight loss. Serum and urine biochemistry were measured during life and at euthanasia. RESULTS: Histology from 25 adult marmosets (19 research and 6 weight loss) showed mesangial expansion in the majority of glomeruli. Mesangial changes correlated with electron-dense deposits and IgM deposition by immunofluorescence; negligible other pathology was seen. Glomerular basement membrane thickness appeared increased compared to reported human measurements. Low-grade proteinuria was present in all animals, but did not progress. Renal function was normal in all animals. CONCLUSIONS: Marmosets develop a glomerulopathy characterized by mesangial expansion, IgM deposition, and proteinuria. This is a benign occurrence and not specifically associated with weight loss.|
|Keywords:||Callitrichidae; glomerular disease; immune complex deposition; mesangium; non-human primates; proteinuria|
|Description:||Article first published online: 30 JUN 2014|
|Rights:||© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd|
|Appears in Collections:||Medicine publications|
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