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|Title:||Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival|
Mc Clure, B.
|Citation:||Molecular Cell, 2000; 6(1):99-108|
|Abstract:||In the hemopoietic compartment, IL-3, GM-CSF, and IL-5 receptors are major transducers of survival signals; however, the receptor-proximal events that determine this vital function have not been defined. We have found that IL-3 stimulation induces phosphorylation of Ser-585 of beta(c). This promotes the association of phospho-Ser-585 of beta(c) with 14-3-3 and the p85 subunit of PI 3-K. Mutation of Ser-585 specifically impairs the PI 3-K signaling pathway and reduces cell survival in response to IL-3. These results define a distinct IL-3 receptor-mediated survival pathway regulated by site-specific receptor serine phosphorylation and 14-3-3 binding and suggest that this novel mode of signaling may be utilized by disparate transmembrane receptors that have as a common theme the transduction of survival signals.|
|Keywords:||Cell Line; Hematopoietic System; Animals; Mice; Tyrosine 3-Monooxygenase; Cyclic AMP-Dependent Protein Kinases; Serine; 14-3-3 Proteins; Proteins; Interleukin-3; Receptors, Interleukin-3; Mutagenesis, Site-Directed; Signal Transduction; Cell Division; Cell Survival; Binding Sites; Amino Acid Sequence; Phosphorylation; Phosphatidylinositol 3-Kinases|
|Appears in Collections:||Medicine publications|
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