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https://hdl.handle.net/2440/9698
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Type: | Journal article |
Title: | Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival |
Author: | Guthridge, M. Stomski, F. Barry, E. Winnall, W. Woodcock, J. Mc Clure, B. Dottore, M. Berndt, M. Lopez, A. |
Citation: | Molecular Cell, 2000; 6(1):99-108 |
Publisher: | Cell Press |
Issue Date: | 2000 |
ISSN: | 1097-2765 1097-4164 |
Abstract: | In the hemopoietic compartment, IL-3, GM-CSF, and IL-5 receptors are major transducers of survival signals; however, the receptor-proximal events that determine this vital function have not been defined. We have found that IL-3 stimulation induces phosphorylation of Ser-585 of beta(c). This promotes the association of phospho-Ser-585 of beta(c) with 14-3-3 and the p85 subunit of PI 3-K. Mutation of Ser-585 specifically impairs the PI 3-K signaling pathway and reduces cell survival in response to IL-3. These results define a distinct IL-3 receptor-mediated survival pathway regulated by site-specific receptor serine phosphorylation and 14-3-3 binding and suggest that this novel mode of signaling may be utilized by disparate transmembrane receptors that have as a common theme the transduction of survival signals. |
Keywords: | Cell Line Hematopoietic System Animals Mice Tyrosine 3-Monooxygenase Cyclic AMP-Dependent Protein Kinases Serine 14-3-3 Proteins Proteins Interleukin-3 Receptors, Interleukin-3 Mutagenesis, Site-Directed Signal Transduction Cell Division Cell Survival Binding Sites Amino Acid Sequence Phosphorylation Phosphatidylinositol 3-Kinases |
DOI: | 10.1016/S1097-2765(05)00002-X |
Published version: | http://dx.doi.org/10.1016/s1097-2765(05)00002-x |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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