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https://hdl.handle.net/2440/9754
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Type: | Journal article |
Title: | Apolipoprotein-D: A novel cellular marker for HGPIN and prostate cancer |
Author: | Hall, R. Horsfall, D. Stahl, J. Vivekanandan, S. Ricciardelli, C. Stapleton, A. Scardino, P. Neufing, P. Tilley, W. |
Citation: | The Prostate, 2004; 58(2):103-108 |
Publisher: | Wiley-Liss |
Issue Date: | 2004 |
ISSN: | 0270-4137 1097-0045 |
Statement of Responsibility: | R.E. Hall, D.J. Horsfall, J. Stahl, S. Vivekanandan, C. Ricciardelli, A.M.F. Stapleton, P.T. Scardino, P. Neufing, and Wayne D. Tilley |
Abstract: | <h4>Background</h4>High grade prostatic intraepithelial neoplasia (HGPIN) is a putative pre-malignant lesion of the prostate. While apolipoprotein-D (Apo-D), an androgen-regulated hydrophobic transporter protein, is expressed in prostate tumors, its expression in HGPIN is unknown.<h4>Methods</h4>Immunoreactivity for Apo-D and another androgen-regulated protein, prostate specific antigen (PSA), was investigated in 64 radical prostatectomy tissues by video image analysis.<h4>Results</h4>Eighty two percent of prostatectomy specimens demonstrated moderate to strong Apo-D immunoreactivity in areas of HGPIN. In comparison, weak Apo-D immunoreactivity was observed in non-malignant areas in only 24% of specimens. The median (range) percentage cellular area of HGPIN immunopositive for Apo-D (9.7%, 0-42.9), and the cellular concentration of Apo-D (MIOD 3.1, 0-13.3), were intermediate between that of normal (area 0%, 0-53.5%, MIOD 0, 0-12.6) and early stage prostate cancer tissues (area 29.2%, 0-90.8%, MIOD 6.7, 0-28.1). This increase in Apo-D expression from non-malignant, through HGPIN to prostate cancer was statistically significant (P < 0.001), and contrasted with the decrease observed in PSA staining between adjacent areas of normal glands, HGPIN, and cancer (P = 0.026).<h4>Conclusions</h4>The presence of high levels of immunoreactive Apo-D in HGPIN and prostate cancer, but not in non-malignant epithelial cells, is consistent with HGPIN being an intermediate lesion in the transition to prostate cancer, and suggests that cellular Apo-D expression is a marker of malignant transformation of the prostate. |
Keywords: | apolipoprotein-D prostate specific antigen prostatic intraepithelial neoplasia radical prostatectomy |
Description: | The definitive version may be found at www.wiley.com |
Rights: | Copyright © 2003 Wiley-Liss, Inc. |
DOI: | 10.1002/pros.10343 |
Published version: | http://www3.interscience.wiley.com/cgi-bin/abstract/106567915 |
Appears in Collections: | Aurora harvest Medicine publications Obstetrics and Gynaecology publications |
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