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|Title:||Apolipoprotein-D: A novel cellular marker for HGPIN and prostate cancer|
|Citation:||Prostate, 2004; 58(2):103-108|
|R.E. Hall, D.J. Horsfall, J. Stahl, S. Vivekanandan, C. Ricciardelli, A.M.F. Stapleton, P.T. Scardino, P. Neufing, and Wayne D. Tilley|
|Abstract:||BACKGROUND: High grade prostatic intraepithelial neoplasia (HGPIN) is a putative pre-malignant lesion of the prostate. While apolipoprotein-D (Apo-D), an androgen-regulated hydrophobic transporter protein, is expressed in prostate tumors, its expression in HGPIN is unknown. METHODS: Immunoreactivity for Apo-D and another androgen-regulated protein, prostate specific antigen (PSA), was investigated in 64 radical prostatectomy tissues by video image analysis. RESULTS: Eighty two percent of prostatectomy specimens demonstrated moderate to strong Apo-D immunoreactivity in areas of HGPIN. In comparison, weak Apo-D immunoreactivity was observed in non-malignant areas in only 24% of specimens. The median (range) percentage cellular area of HGPIN immunopositive for Apo-D (9.7%, 0-42.9), and the cellular concentration of Apo-D (MIOD 3.1, 0-13.3), were intermediate between that of normal (area 0%, 0-53.5%, MIOD 0, 0-12.6) and early stage prostate cancer tissues (area 29.2%, 0-90.8%, MIOD 6.7, 0-28.1). This increase in Apo-D expression from non-malignant, through HGPIN to prostate cancer was statistically significant (P < 0.001), and contrasted with the decrease observed in PSA staining between adjacent areas of normal glands, HGPIN, and cancer (P = 0.026). CONCLUSIONS: The presence of high levels of immunoreactive Apo-D in HGPIN and prostate cancer, but not in non-malignant epithelial cells, is consistent with HGPIN being an intermediate lesion in the transition to prostate cancer, and suggests that cellular Apo-D expression is a marker of malignant transformation of the prostate.|
|Keywords:||apolipoprotein-D; prostate specific antigen; prostatic intraepithelial neoplasia; radical prostatectomy|
|Description:||The definitive version may be found at www.wiley.com|
|Rights:||Copyright © 2003 Wiley-Liss, Inc.|
|Appears in Collections:||Obstetrics and Gynaecology publications|
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