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|Title:||Loss of red cell A, B, and H antigens is frequent in myeloid malignancies|
|Citation:||Blood, 2001; 97(11):3633-3639|
|Publisher:||Amer Soc Hematology|
|Tina Bianco, Belinda J. Farmer, Robert E. Sage, and Alexander Dobrovic|
|Abstract:||Loss of A, B, and H antigens from the surface of red blood cells has been a recurrent observation in patients with hematologic malignancy, particularly those malignancies in which the myeloid lineage is involved. To better understand this phenomenon, a 2-color flow cytometric method was developed to determine quantitative and qualitative alterations of A, B, and H antigens in patients with myeloid malignancies. Characteristic patterns, dependent on the genotype, were seen for healthy individuals from each of the blood groups. Fifty-five percent (16/29) of patients of blood group A, B, or AB had a proportion of red cells with decreased expression of A or B antigens compared with no changes in 127 healthy A, B, and AB individuals. In most cases, the changes were not detected by routine serologic typing. The loss of A or B antigens was the primary change in 28% (8/29) of patients. In 17% (5/29) of patients, loss of A or B antigens was an indirect consequence of loss of the precursor H antigen. Alterations involving both the H and the A or B antigens were seen in 10% (3/29) of patients. Loss of H was also detected in 21% (6/28) of group O patients whereas none of 51 healthy O individuals showed changes. Alterations of ABO antigens can now be considered a common event in myeloid malignancy.|
|Keywords:||Erythrocytes; Humans; Myelodysplastic Syndromes; Myeloproliferative Disorders; ABO Blood-Group System; Flow Cytometry; Genotype; Adult; Leukemia, Myeloid, Acute|
|Description:||© 2001 by The American Society of Hematology|
|Appears in Collections:||Medicine publications|
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