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Type: Journal article
Title: Altered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancy
Author: Sime, F.B.
Roberts, M.S.
Warner, M.S.
Hahn, U.
Robertson, T.A.
Yeend, S.
Phay, A.
Lehman, S.
Lipman, J.
Peake, S.L.
Roberts, J.A.
Citation: Antimicrobial Agents and Chemotherapy, 2014; 58(6):3533-3537
Publisher: American Society for Microbiology
Issue Date: 2014
ISSN: 0066-4804
Statement of
Fekade Bruck Sime, Michael S. Roberts, Morgyn S. Warner, Uwe Hahn, Thomas A. Robertson, Sue Yeend, Andy Phay, Sheila Lehman, Jeffrey Lipman, Sandra L. Peake, Jason A. Roberts
Abstract: This study assessed the pharmacokinetics and dosing adequacy of piperacillin in febrile neutropenic patients after the first dose. Pharmacokinetic analysis was performed using noncompartmental methods. We observed an elevated volume of distribution (29.7 ± 8.0 liters [mean ± standard deviation]) and clearance (20.2 ± 7.5 liters/h) compared to data from other patient populations. Antibiotic exposure did not consistently result in therapeutic targets. We conclude that alternative dosing strategies guided by therapeutic drug monitoring may be required to optimize exposure.
Keywords: Humans
Hematologic Neoplasms
Anti-Bacterial Agents
Middle Aged
Rights: Copyright © 2014, American Society for Microbiology. All Rights Reserved.
DOI: 10.1128/AAC.02340-14
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