Genome sequence, comparative analysis, and population genetics of the domestic horse
Date
2009
Authors
Wade, C.
Giulotto, E.
Sigurdsson, S.
Zoli, M.
Gnerre, S.
Imsland, F.
Lear, T.
Adelson, D.
Bailey, E.
Bellone, R.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Science, 2009; 326(5954):865-867
Statement of Responsibility
C. M. Wade... D. L. Adelson... J. M. Raison... et al.
Conference Name
Abstract
We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.