Genome sequence, comparative analysis, and population genetics of the domestic horse

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dc.contributor.authorWade, C.
dc.contributor.authorGiulotto, E.
dc.contributor.authorSigurdsson, S.
dc.contributor.authorZoli, M.
dc.contributor.authorGnerre, S.
dc.contributor.authorImsland, F.
dc.contributor.authorLear, T.
dc.contributor.authorAdelson, D.
dc.contributor.authorBailey, E.
dc.contributor.authorBellone, R.
dc.contributor.authorBlocker, H.
dc.contributor.authorDistl, O.
dc.contributor.authorEdgar, R.
dc.contributor.authorGarber, M.
dc.contributor.authorLeeb, T.
dc.contributor.authorMauceli, E.
dc.contributor.authorMacleod, J.
dc.contributor.authorPENEDO, M.
dc.contributor.authorRaison, J.
dc.contributor.authorSharpe, T.
dc.contributor.authoret al.
dc.date.issued2009
dc.description.abstractWe report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.
dc.description.statementofresponsibilityC. M. Wade... D. L. Adelson... J. M. Raison... et al.
dc.identifier.citationScience, 2009; 326(5954):865-867
dc.identifier.doi10.1126/science.1178158
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.orcidAdelson, D. [0000-0003-2404-5636]
dc.identifier.urihttp://hdl.handle.net/2440/57814
dc.language.isoen
dc.publisherAmer Assoc Advancement Science
dc.source.urihttps://doi.org/10.1126/science.1178158
dc.subjectBroad Institute Genome Sequencing Platform
dc.subjectBroad Institute Whole Genome Assembly Team
dc.subjectChromosomes, Mammalian
dc.subjectCentromere
dc.subjectAnimals
dc.subjectAnimals, Domestic
dc.subjectDogs
dc.subjectHorses
dc.subjectHumans
dc.subjectChromosome Mapping
dc.subjectSequence Analysis, DNA
dc.subjectComputational Biology
dc.subjectEvolution, Molecular
dc.subjectPhylogeny
dc.subjectRepetitive Sequences, Nucleic Acid
dc.subjectSynteny
dc.subjectHaplotypes
dc.subjectGenes
dc.subjectGenome
dc.subjectMolecular Sequence Data
dc.subjectFemale
dc.subjectDNA Copy Number Variations
dc.titleGenome sequence, comparative analysis, and population genetics of the domestic horse
dc.typeJournal article
pubs.publication-statusPublished

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