A tetranuclear polypyridylruthenium(II) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium

Date

2023

Authors

Wardhani, K.
Levina, A.
Sun, B.
Grau, G.E.R.
Keene, F.R.
Collins, J.G.
Lay, P.A.

Editors

Advisors

Journal Title

Journal ISSN

Volume Title

Type:

Journal article

Citation

Chemical Communications, 2023; 59(45):6877-6880

Statement of Responsibility

Kartika Wardhani, Aviva Levina, Biyun Sun, Georges E. R. Grau, F. Richard Keene, J. Grant Collins and Peter A. Lay

Conference Name

Abstract

A new photoluminescent polypyridylruthenium(II) stain for extracellular vesicles (EVs) released from lipopolysaccharide-stimulated THP-1 monocytes enabled important new insights into how the bacteria-induced immune system affects the blood-brain barrier (BBB). These included previously unknown aspects of EV interactions with BBB microvascular endothelial cells and the extracellular matrix relevant to human brain diseases.

School/Discipline

Dissertation Note

Provenance

Description

Access Status

Rights

This journal is © The Royal Society of Chemistry 2023

License

Call number

Persistent link to this record