A tetranuclear polypyridylruthenium(II) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium
Date
2023
Authors
Wardhani, K.
Levina, A.
Sun, B.
Grau, G.E.R.
Keene, F.R.
Collins, J.G.
Lay, P.A.
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Journal article
Citation
Chemical Communications, 2023; 59(45):6877-6880
Statement of Responsibility
Kartika Wardhani, Aviva Levina, Biyun Sun, Georges E. R. Grau, F. Richard Keene, J. Grant Collins and Peter A. Lay
Conference Name
Abstract
A new photoluminescent polypyridylruthenium(II) stain for extracellular vesicles (EVs) released from lipopolysaccharide-stimulated THP-1 monocytes enabled important new insights into how the bacteria-induced immune system affects the blood-brain barrier (BBB). These included previously unknown aspects of EV interactions with BBB microvascular endothelial cells and the extracellular matrix relevant to human brain diseases.
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This journal is © The Royal Society of Chemistry 2023