A tetranuclear polypyridylruthenium(II) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium

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dc.contributor.authorWardhani, K.
dc.contributor.authorLevina, A.
dc.contributor.authorSun, B.
dc.contributor.authorGrau, G.E.R.
dc.contributor.authorKeene, F.R.
dc.contributor.authorCollins, J.G.
dc.contributor.authorLay, P.A.
dc.date.issued2023
dc.description.abstractA new photoluminescent polypyridylruthenium(II) stain for extracellular vesicles (EVs) released from lipopolysaccharide-stimulated THP-1 monocytes enabled important new insights into how the bacteria-induced immune system affects the blood-brain barrier (BBB). These included previously unknown aspects of EV interactions with BBB microvascular endothelial cells and the extracellular matrix relevant to human brain diseases.
dc.description.statementofresponsibilityKartika Wardhani, Aviva Levina, Biyun Sun, Georges E. R. Grau, F. Richard Keene, J. Grant Collins and Peter A. Lay
dc.identifier.citationChemical Communications, 2023; 59(45):6877-6880
dc.identifier.doi10.1039/d2cc05827h
dc.identifier.issn1359-7345
dc.identifier.issn1364-548X
dc.identifier.orcidKeene, F.R. [0000-0001-7759-0465]
dc.identifier.urihttps://hdl.handle.net/2440/138689
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.relation.granthttp://purl.org/au-research/grants/arc/DP180102741
dc.relation.granthttp://purl.org/au-research/grants/arc/DP210101632
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1099920
dc.rightsThis journal is © The Royal Society of Chemistry 2023
dc.source.urihttps://doi.org/10.1039/d2cc05827h
dc.subjectBlood-Brain Barrier
dc.subjectBrain
dc.subjectEndothelium
dc.subjectEndothelial Cells
dc.subjectHumans
dc.subjectExtracellular Vesicles
dc.titleA tetranuclear polypyridylruthenium(II) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium
dc.typeJournal article
pubs.publication-statusPublished

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