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Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins

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dc.contributor.authorJenkins, C.
dc.contributor.authorPerry, N.
dc.contributor.authorCheasty, T.
dc.contributor.authorShaw, D.
dc.contributor.authorFrankel, G.
dc.contributor.authorDougan, G.
dc.contributor.authorGunn, G.
dc.contributor.authorSmith, H.
dc.contributor.authorPaton, A.
dc.contributor.authorPaton, J.
dc.date.issued2003
dc.description.abstractCertain strains of Shiga toxin-producing Escherichia coli (STEC) which do not have the locus of enterocyte effacement pathogenicity island carry the STEC autoagglutinating adhesin (saa) gene. The distribution of the saa gene in STEC isolates from patients with hemolytic-uremic syndrome (HUS), patients with less severe diarrheal disease, asymptomatic individuals, and healthy cattle was examined. saa-positive strains were detected more frequently (P < 0.001) in STEC strains from bovines (32 of 56 strains) than in those from humans (8 of 91 strains). No significant association (P = 0.135) was found between the saa gene and STEC isolated from patients with HUS (6 of 46 strains) or diarrhea (2 of 29 strains) and from healthy controls (0 of 16 strains).
dc.description.statementofresponsibilityClaire Jenkins, Neil T. Perry, Tom Cheasty, Darren J. Shaw, Gad Frankel, Gordon Dougan, George J. Gunn, Henry R. Smith, Adrienne W. Paton, and James C. Paton
dc.identifier.citationJournal of Clinical Microbiology, 2003; 41(4):1775-1778
dc.identifier.doi10.1128/JCM.41.4.1775-1778.2003
dc.identifier.issn0095-1137
dc.identifier.issn1098-660X
dc.identifier.orcidPaton, J. [0000-0001-9807-5278]
dc.identifier.urihttp://hdl.handle.net/2440/3041
dc.language.isoen
dc.publisherAmer Soc Microbiology
dc.source.urihttp://jcm.asm.org/cgi/content/abstract/41/4/1775
dc.subjectFeces
dc.subjectAnimals
dc.subjectCattle
dc.subjectHumans
dc.subjectEscherichia coli
dc.subjectEscherichia coli Infections
dc.subjectHemolytic-Uremic Syndrome
dc.subjectDiarrhea
dc.subjectAdhesins, Bacterial
dc.subjectEscherichia coli Proteins
dc.subjectShiga Toxins
dc.titleDistribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins
dc.typeJournal article
pubs.publication-statusPublished

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