Single grating x-ray imaging for dynamic biological systems

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dc.contributor.authorMorgan, K.
dc.contributor.authorPaganin, D.
dc.contributor.authorParsons, D.
dc.contributor.authorDonnelly, M.
dc.contributor.authorYagi, N.
dc.contributor.authorUesugi, K.
dc.contributor.authorSuzuki, Y.
dc.contributor.authorTakeuchi, A.
dc.contributor.authorSiu, K.
dc.contributor.conferenceInternational Workshop on X-Ray and Neutron Phase Imaging with Gratings (5 Mar 2012 - 7 Mar 2012 : Tokyo, Japan)
dc.contributor.editorMomose, A.
dc.contributor.editorYashiro, W.
dc.date.issued2012
dc.description.abstractBiomedical studies are already benefiting from the excellent contrast offered by phase contrast x-ray imaging, but live imaging work presents several challenges. Living samples make it particularly difficult to achieve high resolution, sensitive phase contrast images, as exposures must be short and cannot be repeated. We therefore present a single-exposure, high-flux method of differential phase contrast imaging [1, 2, 3] in the context of imaging live airways for Cystic Fibrosis (CF) treatment assessment [4]. The CF study seeks to non-invasively observe the liquid lining the airways, which should increase in depth in response to effective treatments. Both high spatial resolution and sensitivity are required in order to track micron size changes in a liquid that is not easily differentiated from the tissue on which it lies. Our imaging method achieves these goals by using a single attenuation grating or grid as a reference pattern, and analyzing how the sample deforms the pattern to quantitatively retrieve the phase depth of the sample. The deformations are mapped at each pixel in the image using local cross-correlations comparing each ‘sample and pattern’ image with a reference ‘pattern only’ image taken before the sample is introduced. This produces a differential phase image, which may be integrated to give the sample phase depth.
dc.description.statementofresponsibilityKaye S. Morgan, David M. Paganin, David W. Parsons, Martin Donnelley, Naoto Yagi, Kentaro Uesugi, Yoshio Suzuki, Akihisa Takeuchi and Karen K.W. Siu
dc.identifier.citationAIP Conference Proceedings, 2012 / Momose, A., Yashiro, W. (ed./s), vol.1466, pp.124-129
dc.identifier.doi10.1063/1.4742280
dc.identifier.isbn9780735410725
dc.identifier.issn0094-243X
dc.identifier.issn1551-7616
dc.identifier.orcidParsons, D. [0000-0002-8775-3501] [0000-0003-1746-3290]
dc.identifier.urihttp://hdl.handle.net/2440/77224
dc.language.isoen
dc.publisherSpringer New York LLC
dc.publisher.placeUnited States
dc.relation.grantARC
dc.relation.ispartofseriesAIP Conference Proceedings
dc.rights© 2012 American Institute of Physics
dc.source.urihttps://doi.org/10.1063/1.4742280
dc.subjectPhase contrast x-ray imaging
dc.subjectbiomedical imaging
dc.subjectsynchrotron imaging Cystic Fibrosis
dc.subjectairways
dc.titleSingle grating x-ray imaging for dynamic biological systems
dc.typeConference paper
pubs.publication-statusPublished

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