Modular synthesis of functional libraries by accelerated SuFEx click chemistry
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(Published version)
Date
2024
Authors
Homer, J.A.
Koelln, R.A.
Barrow, A.S.
Gialelis, T.L.
Boiarska, Z.
Steinohrt, N.S.
Lee, E.F.
Yang, W.H.
Johnson, R.M.
Chung, T.
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Journal article
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Chemical Science, 2024; 15(11):3879-3892
Statement of Responsibility
Joshua A. Homer, Rebecca A. Koelln, Andrew S. Barrow, Timothy L. Gialelis, Zlata Boiarska, Nikita S. Steinohrt, Erinna F. Lee, Wen-Hsuan Yang, Robert M. Johnson, Taemoon Chung, Amber N. Habowski, Dharmendra S. Vishwakarma, Debmalya Bhunia, Charlotte Avanzi, Adam D. Moorhouse, Mary Jackson, David A. Tuveson, Scott K. Lyons, Michael J. Lukey, W. Douglas Fairlie, Shozeb M. Haider, Michel O. Steinmetz, Andrea E. Prota and John E. Moses
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Abstract
The Accelerated SuFEx Click Chemistry (ASCC) protocol, adapted to a 96-well plate format, has been applied to the late-stage derivatization of bioactive molecules and array synthesis of anticancer agents, showcasing its potential for drug discovery.
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© 2024 The Author(s). Published by the Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.