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Item Metadata only The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis(Wiley, 2026) Chan, S.; Hon, K.; Dawson, R.E.; Weng, T.; Solujic, J.; Chey, Y.C.J.; Zuiani, J.D.; Perkins, G.B.; Coates, P.T.; Drogemuller, C.; Sanderlin, E.; Huang, L.; Finnie, J.; Rose-John, S.; Badiei, A.; Nguyen, P.; Jenkins, B.J.; Saad, M.I.Background and Purpose: Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI). Currently, there are no effective therapeutic agents to treat AP-induced ALI. Experimental Approach: The expression and function of the protease A Disintegrin and Metalloproteinase 17 (ADAM17) were investigated in two murine models of AP-associated ALI induced by L-arginine or cerulein (ceruletide). A human lung/pancreatic organoids co-culture model of AP-associated ALI was employed to validate ADAM17 up-regulation in vitro. Key Results: ADAM17 expression was up-regulated in pancreatic and lung tissues of wild-type (WT) mice exposed to AP-associated ALI models. The genetic (Adam17ex/ex mice) and therapeutic (antisense oligonucleotides; ASOs) targeting of ADAM17 to reduce its expression in the lungs of mice ameliorated experimentally induced AP-associated lung inflammation, which coincided with the selective reduction in the extracellular shedding of two ADAM17 substrates, soluble tumour necrosis factor α (TNFα) and soluble interleukin-6 receptor (sIL-6R). ADAM17 targeting in AP-associated ALI also suppressed lung inflammatory cell infiltration, including macrophages, as well as cellular death in the lung alveolar compartment. Furthermore, ADAM17 expression was up-regulated by L-arginine or cerulein (ceruletide) in an in vitro human lung/pancreatic organoids co-culture model of AP-associated ALI. Conclusions and Implications: Our findings indicate that the ADAM17 protease plays a crucial role in the pathogenesis of acute lung inflammatory responses during AP progression, which could pave the way for devising novel therapeutic options to treat AP-induced ALI.Item Metadata only Trends and Harms of Election Denialism: The United States and Australia(Taylor and Francis Group, 2026) Hill, L.‘Trends in Election Denialism: the United States and Australia’ ‘Election denialism’ denotes the claim that an election has been ‘stolen’ or rigged either by private individuals or, more disturbingly, by election authorities. Although an increasingly common form of political disinformation, we tend to think of it as a problem largely confined to the US. But, as I show in this empirically-informed political theory paper, it is now also becoming an Australian problem. I lay out and compare the character and extent of the problem in the US and Australia, then show how election conspiracism can, does and may undermine democracy in both settings. I do so by enlisting a proceduralist conception of democracy and democratic legitimacy in order to assess its harms and to comprehend them in relation to the purpose and function of elections in representative democracies. A key theme is to understand why Australia has proved to be more resilient to disinformation about the authenticity of electoral processes and outcomes.Item Open Access TS3 Asn347 corticosteroid-binding globulin (CBG) glycoform deficiency is associated with mortality in human septic shock(Endocrine Society, 2026) Lee, J.H.; Sumer-Bayraktar, Z.; Rushworth, R.L.; Chernykh, A.; Nenke, M.; Thaysen-Andersen, M.; Meyer, E.J.; Torpy, D.J.Context: Corticosteroid-binding globulin (CBG) deficiency is an independent predictor of intensive care unit (ICU) mortality in septic shock. CBG glycosylation at the Asn347 site affects neutrophil elastase cleavage susceptibility, altering CBG:cortisol binding affinity, and may underlie this association. Objective: This work aimed to analyze CBG Asn347 glycoforms in patients with septic shock and determine their relationship to mortality and illness severity. Methods: CBG Asn347 site glycosylation profiling was performed by mass spectrometry in 128 septic shock patients from a tertiary hospital ICU at day 1 and last day of admission up to 7 days. ICU and 28-day mortality were analyzed by a Cox proportional hazards model, sequentially correcting for illness severity (APACHE score) and total CBG (all glycoforms). Results: Only triantennary trisialylated (TS3) Asn347 CBG glycoform concentrations were lower in ICU septic shock nonsurvivors than in survivors (29.74 vs 45.16 nmol/L; P = 0.007). On Cox multivariate analysis correcting for APACHE score, lowest tertile of TS3 Asn347 CBG glycoform concentration (<27.9 nmol/L) was associated with increased ICU mortality (adjusted hazard ratio [HR] 2.7; 95% CI, 1.2-6.2; P = .023) and was the only Asn347 glycoform demonstrating such an association. TS3 Asn347 CBG glycoform concentration less than 27.9 nmol/L was also associated with increased 28-day mortality (adjusted HR 2.2; 95% CI, 1.1-4.4; P = .023), which was not the case with lowest tertile of total CBG concentration (<200 nmol/L). Conclusion: Deficiency of the Asn347 TS3 CBG glycoform is associated with ICU and 28-day mortality in septic shock.Item Open Access Variability in the southern margin of the Indo-Australian Summer Monsoon since 46 ka(Elsevier, 2026) Dixon, T.; Rudd, R.; Kemp, J.; Marx, S.; Moss, P.; Hua, Q.; Bird, M.; Hall, P.A.; McGowan, H.The past ∼50,000 years encompass a series of major climatic transitions, including Marine Isotope Stage 2, the Marine Isotope Stage 2/1 transition, and the onset of the Holocene, when the Earth underwent large shifts in temperature, ice volumes, sea levels and atmospheric circulation patterns. There is a growing body of research focused on the behaviour of the Indo-Australian Summer Monsoon (IASM) during these periods from sites close to Australia’s northern coastlines and currently within the zone of direct monsoon precipitation. However, the relative contributions of latitudinal shifts and/or moisture carrying capacity of the monsoon system on changes in hydroclimate remain uncertain. Here, we present the results from a 46,000-year sediment record obtained at the modern southern extent of rainfall penetration into north-west Australia associated with the IASM. Our results show that the region experienced reduced precipitation until the end of the glacial. During the MIS 2/1 transition and the early Holocene, there is evidence of an increase in wet-season precipitation, likely limited to extreme events occasionally reaching the site. More pronounced and sustained shifts in precipitation were limited to the late Holocene, during which the variability recorded at the site aligned with that interpreted from records further to the north in Australia. We interpret this as reflecting a time-transgressive southward shift in the southern limit of the monsoon system.Item Open Access All-sky Neutrino Point-source Search with IceCube Combined Track and Cascade Data(IOP Publishing, 2025) Abbasi, R.; Ackermann, M.; Adams, J.; Agarwalla, S.K.; Aguilar, J.A.; Ahlers, M.; Alameddine, J.M.; Ali, S.; Amin, N.M.; Andeen, K.; Argüelles, C.; Ashida, Y.; Athanasiadou, S.; Axani, S.N.; Babu, R.; Bai, X.; Baines-Holmes, J.; Balagopal, A.; Barwick, S.W.; Bash, S.; et al.Despite extensive efforts, discovery of high-energy astrophysical neutrino sources remains elusive. We present an event-level simultaneous maximum likelihood analysis of tracks and cascades using IceCube data collected from 2008 April 6 to 2022 May 23 to search the whole sky for neutrino sources, and using a source catalog, for coincidence of neutrino emission with gamma-ray emission. This is the first time a simultaneous fit of different detection channels is used to conduct a time-integrated all-sky scan with IceCube. Combining all-sky tracks, with superior pointing power and sensitivity in the northern sky, with all-sky cascades, with good energy resolution and sensitivity in the southern sky, we have developed the most sensitive point-source search to date by IceCube that targets the entire sky. The most significant point in the northern sky aligns with NGC 1068, a Seyfert II galaxy, which, from the catalog search, shows a 3.5σ excess over background after accounting for trials. The most significant point in the southern sky does not align with any source in the catalog and is not significant after accounting for trials. A search for the single most significant Gaussian flare at the locations of NGC 1068, PKS 1424+240, and the southern highest-significance point shows results consistent with expectations for steady emission. Notably, this is the first time that a flare shorter than four years has been excluded as being responsible for NGC 1068’s emergence as a neutrino source. Our results show that combining tracks and cascades when conducting neutrino source searches improves sensitivity and can lead to new discoveries.Item Metadata only Law's Dream: The Natural Law Outlook, Normativity and Purpose in Legal Education(Edinburgh University Press, 2026) Lee, C.; Cooper, L.Modern legal education presumes law’s utility but questions its vision. However, law’s intrinsic purpose has long animated jurisprudential enquiry; jurisprudence being the cornerstone of orthodox legal education, the course tasked with probing law’s nature, rationale, and aspirations. Within this traditional pedagogical framework, natural law theory occupied a central place, offering a paradigm through which students could explore how law, though distinct from morality, is inseparably entwined with the pursuit of justice. Yet in recent years, jurisprudence has taken a back seat in the legal curriculum as law’s vision becomes less clear. Law’s purpose either conceived as a necessary measure for social coordination, or simply as a matter of source seem now to be the only available conclusions. This article argues that these conclusions are both premature and unsatisfactory. We proceed on this basis (without casting aspersions on any group or individual) to observe that there has been a general movement away from such philosophical enquiries in modern Western legal systems and that this pedagogical turn coincides with the growing integration of law into other interdisciplinary domains. This approach to legal education values law, not for its unique nature, but its usefulness. We enter the conversation at this juncture, not simply to lament these developments, but to argue for the conceptual necessity of the natural law outlook for any cogent attempt at legal education.Item Open Access Field Evaluation of a Constructed Floating Wetland for Nutrients and PFAS Attenuation in a Treatment Lagoon(American Chemical Society, 2026) Awad, J.; Lu, W.; Walker, C.; Malerba, M.; Schuster, L.; Navarro, D.Constructed floating wetlands (CFWs) provide a passive pathway for the retention and accumulation of nutrients and perfluoroalkyl and polyfluoroalkyl substances (PFAS) present in treated wastewater (TWW). This two-year field-scale study investigated the accumulation of PFAS and nutrients in three native wetland species in a lagoon setting. During the plant establishment period and despite measurable nutrient and PFAS uptake in plant tissues, their removal from the water was limited due to short residence times (∼10–12 h). The highest nutrient accumulation in shoots was observed in Phragmites australis (0.14 g N/m2/day and 0.02 g P/m2/day), which showed the highest biomass (12.1 g/m2/day). Phragmites australis also exhibited the highest PFAS and precursor accumulation in tissues. PFAS removal improved after plant establishment, and the daily removal rate for PFAS (based on PFAS accumulation in plant tissue and sediment) was 240 ng/m2/d. Overall, CFWs show promise as a passive, modular solution for PFAS reduction in TWW, particularly after root system development and biofilm formation. However, long-term monitoring across multiple growth and harvest cycles and assessing the contribution of other mechanisms (such as sorption to growth media and accumulation in biofilms) are required to evaluate the CFW system sustainability under varying environmental conditions.Item Open Access Association of physical and social neighbourhood environment with movement behaviours among schoolchildren: a compositional data analysis(BMC, 2026) Xing, R.; Rachele, J.N.; Loh, V.; Dumuid, D.; Pedišić, Ž.Background: How schoolchildren distribute their time between movement behaviours may be impacted by the neighbourhood environment. Few studies have investigated the associations between the physical and social environment and the full movement behaviour composition, including times spent in moderate-to-vigorous physical activity (MVPA), light physical activity (LPA), sedentary behaviour, and sleep, and their findings are inconsistent. Therefore, our aim was to investigate this association in a large, national-representative sample of schoolchildren from major cities and regional/remote areas. Methods: We used data from the Longitudinal Study of Australian Children and the Child Health CheckPoint study, collected among 1230 child-parent pairs (child age range: 10–12 years). Parents were asked about neighbourhood general safety, access to destinations and services, and social capital and cohesion. Children’s time spent in MVPA, LPA, sedentary behaviour, and sleep was assessed using wrist-worn GENEActiv accelerometers. The associations between the physical and social environment characteristics (independent variables) and movement behaviour composition expressed as isometric log ratio coordinates (dependent variables) were examined using multiple linear regression analyses, adjusted for age, body mass index, pubertal status, sex, and socioeconomic position. Results: Among schoolchildren from regional/remote areas, access to destinations and services (Pillai’s trace = 0.030; p = 0.010), as well as social capital and cohesion (Pillai’s trace = 0.024; p = 0.032) were associated with movement behaviour composition. In specific, better access to destinations and services was associated with higher MVPA and lower LPA, while higher social capital and cohesion were associated with higher MVPA and LPA, and lower sedentary behaviour (with negligible changes in the remaining movement behaviours). We did not find a significant association between general safety and the movement behaviour composition among schoolchildren from regional/remote areas (Pillai’s trace = 0.005; p = 0.641) or any significant associations among schoolchildren from major cities (p > 0.050 for all).Conclusions: These findings highlight the importance of access to destinations and services, as well as social capital and cohesion, in shaping the movement behaviour composition among schoolchildren from regional/remote areas. More research is needed to draw conclusions about the association between neighbourhood environment and movement behaviour composition among schoolchildren from major cities.Item Metadata only Bayesian tip-dating and biogeographic approaches reveal multiple marine transitions in Pan-Chelonioidea and a North Atlantic origin for modern sea turtles (Chelonioidea)(Oxford University Press, 2026) Chatterji, R.M.; Hutchinson, M.N.; Jones, M.E.H.Convergent evolution can undermine parsimony as a criterion for choosing among phylogenetic hypotheses, resulting in a challenge to find consensus among conflicting trees. This challenge is exemplified in the studies of sea turtle (Pan-Chelonioidea) evolution. Despite the wide interest in this iconic clade, rigorous analyses of character acquisition are currently limited by poorly resolved, largely parsimony-based phylogenies. In particular, there is uncertainty regarding the placement of the extinct family Protostegidae, which has been recovered in several different parts of the tree and even outside Pan-Chelonioidea as a separate radiation of marine turtles. The relationships among the stem of Cheloniidae are also far from a consensus, despite it having a relatively good fossil record. Here we investigate the evolution of sea turtles using a Bayesian tip-dating approach, a technique not previously applied to this group. We also conduct a biogeographic analysis using DEC and DECJ models. We find Protostegidae to be sister to the rest of Pan-Chelonioidea, implying convergent evolution of the sea turtle flipper and other marine adaptations. We find that Chelonioidea probably originated in the North Atlantic, and that the now global distribution of most sea turtle species suggests that the pelagic life phase of extant species is unique to crown Cheloniidae.Item Metadata only Gender and Sexuality in Childhood Emotional Abuse: An Exploration of Victim-survivor Experiences in Australia(Springer, 2026) Moulding, N.; McLinton, S.; Borgkvist, A.; Tseris, E.; Buchanan, F.; Fawcett, B.Purpose: This article reports on a research project that aimed to generate new knowledge about the social dimensions of childhood emotional abuse. The driving research question for the overarching study asked how social context shapes and structures childhood emotional abuse, with the two sub-questions specifically relevant to this paper asking how the severity of childhood emotional abuse might vary according to the gender and sexual identity of victim-survivors, and how gender power relations frame these abusive practices. Methods: The study used a mixed method involving a national quantitative and qualitative survey (N = 472), and qualitative in-depth interviews and narrative-discursive analysis (N = 31). Results: Quantitative analysis revealed that cisgender heterosexual women, and people of diverse genders and sexualities, report significantly higher frequencies of certain types of gendered childhood emotional abuse compared to cisgender heterosexual men. Qualitative analysis revealed the heteronormative gender discourses driving these abusive practices. Conclusions: Some forms of childhood emotional abuse can be understood as rather brutal forms of gendering within families, which might help to explain existing evidence that women and individuals who are gender and sexually diverse experience higher levels of distress down track than cisgender heterosexual men.Item Open Access Gender sensitive approach in response to climate change: Why and how?(SAGE Publishing, 2026) Salam, R.A.; Lassi, Z.S.Global gender inequalities are intensifying, driven by intersecting social, political, and environmental pressures. Recent evidence shows that women bear a disproportionate burden of poverty, food insecurity, poor health, and gender-based violence. Climate change further compounds these vulnerabilities, threatening to reverse hard-won gains in gender equality, particularly in fragile and low-resource settings. Without urgent, gender-responsive and climate-informed action, millions more women and girls risk being pushed into extreme poverty in the coming decades.Item Metadata only Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study(Nature Research, 2026) Kang, J.; Kim, H.J.; Kim, M.S.; Zyoud, S.H.; Zielińska, M.; Zhu, B.; Zhong, A.; Zhang, J.; Zhang, H.; Zeariya, M.G.M.; Zanghì, A.; Zakham, F.; Yusuf, H.; Yu, C.; Yonemoto, N.; Yip, P.; Yin, D.; Yesodharan, R.; Yahaya, Z.S.; Wilandika, A.; et al.Drug use disorders (DUDs) are emerging global public health challenges. Here we investigated the global and regional estimates of the prevalence and burden of DUDs, including amphetamine, cannabis, cocaine and opioid use disorders, from 1990 to 2023 for 204 countries and territories by using the Global Burden of Disease Study 2023. Overall, trends in global age-standardized disability-adjusted life-years of DUDs increased from 169.3 (95% uncertainty interval (95% UI), 134.4-203.9) per 100,000 people in 1990 to 212.0 (95% UI, 179.2-245.6) in 2023. In 2023, both prevalence and burden of DUDs were higher in high-income countries, particularly in the USA. The most prevalent DUDs in 2023 were cannabis use disorder (age-standardized prevalence, 270.8 (95% UI, 201.7-350.0) per 100,000 people) and opioid use disorder (205.9 (95% UI, 178.7-235.0)). Particularly, opioid use disorder showed a nearly twofold increase in prevalence and burden between 1990 and 2023. In 2023, compared with countries where cannabis use was illegal, countries permitting both recreational and medical cannabis use had higher prevalence rates for all types of DUDs. Proactive and effective policies are essential to mitigate the increasing global burden of DUDs.Item Metadata only Highly Reversible Aqueous Anode-Free Cadmium-Bromine Batteries(Wiley, 2026) Zhao, X.; Zhu, Y.; Chen, Q.; Ma, R.; Hao, J.; Qiao, S.-Z.Aqueous anode-free zinc (Zn)-based batteries promise high energy density; however, their reversibility and lifespan are hampered by dendritic growth, hydrogen evolution, and poor Zn utilization (<20%). Cadmium (Cd), a close analogue of Zn, presents a viable alternative. Here, we systematically compare both Zn and Cd anodes in aqueous media, showing that Cd features dendrite-free deposition, suppressed side reactions, and stable cycling at anode utilization up to 75%. Benefiting from these advances, we demonstrate the first aqueous anode-free cadmium-bromine (Cd-Br) battery. To boost Cd2+ plating kinetics in an anode-free Cd-Br battery, LiCl is introduced into CdSO4 electrolyte to reconstruct the Cd2+ solvation shell, resulting in accelerated desolvation and deposition kinetics. Consequently, anode-free Cd-Br coin cells achieve 87.6% capacity retention after 2000 cycles at 4 C, significantly superior to the anode-free Zn-Br coin cells with 12.4% retention after only 50 cycles and outperforming other reported aqueous anode-free systems. Moreover, scaled-up aqueous anode-free Cd-Br pouch cells exhibit stable cycling over 1250 cycles with capacity retention of 83.8% and high energy density of 157 Wh kg-1, far exceeding that of state-of-the-art Zn-Mn and Zn-V pouch cells. This work establishes anode-free Cd-Br chemistry as a new paradigm in developing high-energy and highly reversible aqueous batteries.Item Open Access Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes(American Chemical Society, 2021) Eduful, B.J.; O'Byrne, S.N.; Temme, L.; Asquith, C.R.M.; Liang, Y.; Picado, A.; Pilotte, J.R.; Hossain, M.A.; Wells, C.I.; Zuercher, W.J.; Catta-Preta, C.M.C.; Zonzini Ramos, P.; Santiago, A.D.S.; Couñago, R.M.; Langendorf, C.G.; Nay, K.; Oakhill, J.S.; Pulliam, T.L.; Lin, C.; Awad, D.; et al.CAMKK2 is a serine/threonine kinase and an activator of AMPK whose dysregulation is linked with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to probe CAMKK2 signaling, has limitations. To identify promising scaffolds as starting points for the development of high-quality CAMKK2 chemical probes, we utilized a hinge-binding scaffold hopping strategy to design new CAMKK2 inhibitors. Starting from the potent but promiscuous disubstituted 7-azaindole GSK650934, a total of 32 compounds, composed of single-ring, 5,6-, and 6,6-fused heteroaromatic cores, were synthesized. The compound set was specifically designed to probe interactions with the kinase hinge-binding residues. Compared to GSK650394 and STO-609, 13 compounds displayed similar or better CAMKK2 inhibitory potency in vitro, while compounds 13g and 45 had improved selectivity for CAMKK2 across the kinome. Our systematic survey of hinge-binding chemotypes identified several potent and selective inhibitors of CAMKK2 to serve as starting points for medicinal chemistry programs.Item Open Access Impact of Antenatal Corticosteroids on Brain Function and Underlying Mechanisms in Preclinical Studies: Protocol for a Systematic Review(JMIR Publications, 2026) Herselman, M.F.; Hislop, T.; McBride, S.D.; Lock, M.C.; Morrison, J.L.; Gatford, K.L.BACKGROUND: Antenatal corticosteroid (ACS) treatment matures the fetal lung and reduces risks of neonatal morbidity and mortality in babies born preterm. However, ACS treatment also impacts the brain and stress regulatory systems, with increasing clinical evidence for adverse long-term impacts. Preclinical studies are important to investigate the mechanisms for these impacts. OBJECTIVE: This systematic review aims to synthesize the best available evidence describing how in utero exposure to ACS affects brain function, the underlying mechanisms, and the hypothalamic-pituitary-adrenal axis in nonhuman mammalian species. METHODS: This review will include peer-reviewed, primary studies that report measures of brain function (eg, learning, behavior) and the underlying mechanisms (eg, brain size, neuron number, myelination, hypothalamic-pituitary-adrenal axis function) in nonhuman mammals exposed in utero to ACS in the second half of pregnancy, in comparison to unexposed individuals. Initial search terms include (corticosteroid* OR glucocorticoid*) AND (antenatal OR fetal* OR pregnan*) AND (brain OR neurodevelopment*). We searched PubMed, Embase, MEDLINE (Ovid), Web of Science, Scopus, and ProQuest for English language publications without date restrictions. Two independent reviewers will perform abstract screening, data extraction, and quality assessment. Antenatal corticosteroid treatment information, study design, methods, and outcomes will be reported for each study. RESULTS: A narrative synthesis will be presented following standard guidelines. A dose-response meta-analysis will be performed where at least three studies report the same outcome following in utero exposure to the same steroid. As of February 21, 2026, title and abstract screening were completed for 42,024 of 56,493 records, with 40,795 records excluded. Searches will be updated in June-July 2026 to include sources published to the end of 2025. Publication is planned for 2027. CONCLUSIONS: This review will inform future research including intervention studies to reduce the adverse effects of antenatal corticosteroids on the brain.Item Open Access Bislawsone as a robust redox mediator for high-performance aqueous polysulfide redox flow batteries(Cell Press, 2026) Chen, Q.; Zhu, Y.; Zhang, S.-J.; Zhao, X.; Tian, Z.; Hao, J.; Qiao, S.-Z.Aqueous redox flow batteries (RFBs) are a safe and scalable technology for storing energy from intermittent renewable sources such as solar and wind. The most mature system, all-vanadium RFBs, has already been commercialized. However, vanadium is unevenly distributed worldwide and in high demand for steel production, which keeps its price high (∼$10.5 per kilogram) and limits the economic competitiveness of vanadium-based RFBs. Sulfur offers a far more affordable alternative (∼$0.106 per kilogram) and has inspired the development of polysulfide RFBs. However, sluggish reaction kinetics lead to poor energy efficiency and a low usable capacity. Conventional solid catalysts can accelerate the reaction but typically fail to maintain performance beyond 400 cycles. Recently, riboflavin sodium phosphate (FMN-Na) was introduced as a molecular catalyst, yielding batteries with improved cycling stability. Nevertheless, FMN-Na degradation raises concern that long-term energy efficiency may be compromised. Here, we introduce bislawsone as a novel redox mediator, distinguished by its quinone-based redox core, in contrast to the isoalloxazine skeleton of FMN-Na. Bislawsone accelerates the polysulfide reaction by shuttling electrons from the electrode to polysulfide and continuously regenerating itself for repeated use. The resulting battery achieves the highest energy efficiency reported for fully charged/discharged polysulfide RFBs. The usable capacity is increased from less than 1% to over 95% at high current, surpassing that of all solid-catalyst counterparts. Most importantly, the bislawsone-polysulfide system maintains over 92% of its initial energy efficiency after 2,200 cycles, establishing a new benchmark for long-term durability. By combining sulfur’s cost advantages with a robust molecular mediator, this work addresses a key bottleneck for polysulfide RFBs and provides a pathway toward practical, low-cost, long-duration energy storage to support the global transition to renewable power.Item Metadata only Intrauterine human chorionic gonadotropin administration before embryo transfer (IHABT): an individual participant data meta-analysis of randomized controlled trials(Oxford University Press, 2026) Zou, H.; Abdallah, K.S.; Wirleitner, B.; Hong, K.H.; Thanaboonyawat, I.; Laokirkkiat, P.; Hafezi, M.; Kokeguchi, S.; Makhlouf, A.; Libesman, S.; Nguyen, D.; Williams, J.G.; Showell, M.; Gadalla, M.; Mol, B.W.J.; Li, W.; Wang, R.BACKGROUND Intrauterine administration of hCG has been considered as a promising IVF add-on before embryo transfer to improve fertility outcomes. A Cochrane review and four more recent systematic reviews all showed improved clinical pregnancy rates and/or live birth rates following intrauterine administration of hCG, however, a high unexplained heterogeneity was also present. OBJECTIVE AND RATIONALE To investigate the effectiveness and safety of intrauterine administration of hCG before embryo transfer in participants undergoing IVF. Individual participant data meta-analysis (IPD-MA) is recognized as the gold standard for evidence synthesis due to its ability to harmonize the data and to investigate treatment–covariate interactions. In addition, with recent experiences of guideline development and systematic review production raising increasing concerns about the trustworthiness of randomized controlled trials (RCTs) in women’s health research, an IPD-MA provides a unique opportunity to summarize the best available and most trustworthy evidence on this topic. SEARCH METHODS We searched MEDLINE, Embase, Cochrane Gynaecology and Fertility Group Specialised Register, Cochrane Central Register of Controlled Trials, PsycINFO, and clinical trial registries without language restrictions up to January 2026. Inclusion criteria included RCTs comparing intrauterine administration of hCG before embryo transfer versus placebo or no intervention in participants undergoing IVF. The IPD Integrity tool and the TRACT checklist were used to evaluate the trustworthiness of studies with and without IPD, respectively. Both one-stage and two-stage random-effect IPD meta-analyses were performed with one-stage being the primary analysis. OUTCOMES We detected 28 RCTs, of which 7 RCTs with IPD involving 2244 participants were included. All seven RCTs with IPD met trustworthiness criteria and six RCTs had overall low risk of bias. All RCTs without IPD did not meet trustworthiness criteria. IPD-MA showed intrauterine administration of hCG before embryo transfer did not improve live birth rates (7 RCTs, 2244 participants, odds ratio [OR] 0.99, 95% CI 0.83–1.19) or clinical pregnancy rates (7 RCTs, 2244 participants, OR 1.04, 95% CI 0.83–1.31). Studies without IPD showed different results from those with IPD for live birth (1.99, 0.72–5.50, P for interaction <0.001) and clinical pregnancy (1.87 (1.48–2.35), 17 RCTs without IPD, 3152 participants, P for interaction 0.005).Item Metadata only Intrinsic Charge Separation in Pt-Loaded Y-Series Nonfullerene Acceptor Nanoparticles: Implication for the Photocatalytic Hydrogen Evolution Reaction(American Chemical Society, 2026) Dolan, A.; McAfee, H.J.; James Loeliger, M.E.; de la Perrelle, J.M.; Smith, T.A.; Pan, X.; Andersson, M.R.; Dela Peña, T.A.; Ma, R.; Wu, J.; Huang, D.M.; Kee, T.W.Y-series nonfullerene acceptors (NFAs) have previously been investigated as Pt-loaded organic photocatalysts and homojunction solar cells due to their unique ability to generate charge in the absence of a donor material. Here, hydrogen evolution by Pt-loaded organic nanoparticles (NPs) composed of five different Y-series acceptors is compared, to reveal the structural differences in the NFA that lead to an improved photocatalytic hydrogen evolution rate. PY-IT is a polymerized Y-series acceptor that contains a thiophene linker to create a polymer with the core structure shared by the Y-series acceptors. The other acceptors studied, namely L8-BO, PC6, and Y7, have the same core structure as the well studied Y6 NFA but with alterations to side chains or terminal halogens. The results show that PY-IT and L8-BO NPs exhibit the highest hydrogen evolution rate, which is attributed to enhanced structural order and the resulting reduced energetic disorder. The rate of hydrogen evolution of the PY-IT NPs is (50.3 ± 2.5) mmol h–1 g–1, which is over 3.5 times that achieved by the Y6 NPs. Ultrafast spectroscopy measurements indicate enhanced intermolecular exciton dissociation in PY-IT compared with the small-molecule acceptors due to exciton delocalization over the PY-IT polymer chain. Overall, we report hydrogen evolution of Pt-loaded organic NPs PC6, L8-BO, and Y7 for the first time, and clarify the mechanism by which PY-IT exhibits a high hydrogen evolution rate.Item Open Access Blood Pressure Parameters and Risk of Cognitive Decline and Dementia in Type 2 Diabetes: Results From the ADVANCE Trial(Wiley, 2026) Shajahan, S.; Woodward, M.; Anderson, C.S.; Carcel, C.; Wang, N.; Tully, P.J.; Peters, R.; Harrap, S.; Poulter, N.; Mancia, G.; MacMahon, S.; Chalmers, J.; Harris, K.BACKGROUND: Blood pressure (BP) variability and cumulative BP load are significantly associated with cardiovascular disease risk beyond mean systolic BP, but less is known regarding their associations with cognitive decline/dementia and whether these associations differ by cognitive function at baseline or by sex. The aims of this study were to determine associations of different BP parameters with cognitive decline/dementia in patients with type 2 diabetes and explore differences by mild cognitive impairment at baseline and sex. METHODS: Using data from the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation) study, BP parameters were calculated from an 18-month exposure window comprising measurements at 3, 4, 6, 12, and 18 months, after randomization. Logistic regression was used to estimate the odds ratio (OR) per SD higher and 95% CI for the associations of BP parameters with the composite outcome of cognitive decline (≥3 points from baseline on the Mini-Mental State Examination) or clinical diagnosis of dementia. RESULTS: Of the 11 140 ADVANCE participants, 9586 patients had 5 complete BP measurements within the 18-month exposure window. After a mean follow-up of 3.5 years, 1674 (17.5%) participants were diagnosed with cognitive decline and/or dementia. Overall, variability and baseline pulse pressure (PP), but not BP load, were associated with higher odds of cognitive decline/dementia (OR: variability in systolic BP, 1.11 [95% CI, 1.05–1.17]; diastolic BP, 1.11 [95% CI, 1.05–1.17]; PP, 1.05 [95% CI, 1.00–1.11]; mean arterial pressure, 1.13 [95% CI, 1.07–1.19]; and baseline PP, 1.19 [95% CI, 1.13–1.25]). There were no differences by mild cognitive impairment at baseline or sex. CONCLUSIONS: Higher BP variability and baseline PP, but not mean BP or BP load, were associated with higher odds of cognitive decline/dementia in patients with type 2 diabetes. BP variability and PP may be important therapeutic markers for the preservation of brain health. REGISTRATION: URL: https:// clinical trials. gov; Unique Identifier: NCT00145925.Item Open Access Lifting Manifolds to Mitigate Pseudo-Alignment in LLM4TS(ACM, 2026) Zheng, L.N.; Liang, W.; Zhang, W.E.; Xu, M.; Maennel, O.; Chen, W.; The ACM Web Conference 2026 (WWW'26) (13 Apr 2026 - 17 Apr 2026 : Dubai United Arab Emirates)Pseudo-Alignment is a pervasive challenge in many large language models for time series (LLM4TS) models, often causing them to underperform compared to linear models or randomly initialised backbones. However, there is limited discussion in the community for the reasons that pseudo-alignment occurs. In this work, we conduct a thorough investigation into the root causes of pseudo-alignment in LLM4TS and build a connection of pseudo-alignment to the cone effect in LLM. We demonstrate that pseudo-alignment arises from the interplay of cone effect within pretrained LLM components and the intrinsically low-dimensional manifold of time-series data. In addition, we also introduce TimeSUP, a novel technique designed to mitigate this issue and improve forecast performance in existing LLM4TS approaches. TimeSUP addresses this by increasing the time series manifold to more closely match the intrinsic dimension of language embeddings, allowing the model to distinguish temporal signals clearly while still capturing shared structures across modalities. As a result, representations for time and language tokens remain distinct yet exhibit high cosine similarity, signifying that the model preserves each modality's unique features while learning their commonalities in a unified embedding space. Empirically, TimeSUP consistently outperforms state-of-the-art LLM4TS methods and other lightweight baselines on long-term forecasting performance. Furthermore, it can be seamlessly integrated into four existing LLM4TS pipelines and delivers significant improvements in forecasting performance.