Tumor necrosis factor primes neutrophils to kill Staphylococcus aureus by an oxygen-dependent mechanism and Plasmodium falciparum by an oxygen-independent mechanism
Date
1996
Authors
Kowanko, I.
Ferrante, A.
Clemente, G.
Kumaratilake, L.
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Journal article
Citation
Infection and Immunity, 1996; 64(8):3435-3437
Statement of Responsibility
I. C. Kowanko, A. Ferrante, G. Clemente and L. M. Kumaratilake
Conference Name
Abstract
The cytokine tumor necrosis factor (TNF) plays the important role of priming neutrophils for increased antimicrobial activity. We now demonstrate that human neutrophils which lack the ability to generate oxygen radicals, from patients with chronic granulomatous disease, show TNF-induced enhancement of killing of intraerythrocytic stages of Plasmodium falciparum but not of Staphylococcus aureus.
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Copyright © 1996, American Society for Microbiology