Tumor necrosis factor primes neutrophils to kill Staphylococcus aureus by an oxygen-dependent mechanism and Plasmodium falciparum by an oxygen-independent mechanism

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dc.contributor.authorKowanko, I.
dc.contributor.authorFerrante, A.
dc.contributor.authorClemente, G.
dc.contributor.authorKumaratilake, L.
dc.date.issued1996
dc.description.abstractThe cytokine tumor necrosis factor (TNF) plays the important role of priming neutrophils for increased antimicrobial activity. We now demonstrate that human neutrophils which lack the ability to generate oxygen radicals, from patients with chronic granulomatous disease, show TNF-induced enhancement of killing of intraerythrocytic stages of Plasmodium falciparum but not of Staphylococcus aureus.
dc.description.statementofresponsibilityI. C. Kowanko, A. Ferrante, G. Clemente and L. M. Kumaratilake
dc.identifier.citationInfection and Immunity, 1996; 64(8):3435-3437
dc.identifier.doi10.1128/iai.64.8.3435-3437.1996
dc.identifier.issn0019-9567
dc.identifier.issn1098-5522
dc.identifier.orcidFerrante, A. [0000-0002-2581-6407]
dc.identifier.urihttp://hdl.handle.net/2440/14640
dc.language.isoen
dc.publisherAMER SOC MICROBIOLOGY
dc.rightsCopyright © 1996, American Society for Microbiology
dc.source.urihttp://iai.asm.org/cgi/content/abstract/64/8/3435
dc.subjectErythrocytes
dc.subjectAnimals
dc.subjectHumans
dc.subjectPlasmodium falciparum
dc.subjectStaphylococcus aureus
dc.subjectGranulomatous Disease, Chronic
dc.subjectReactive Oxygen Species
dc.subjectTumor Necrosis Factor-alpha
dc.subjectFree Radical Scavengers
dc.subjectNeutrophil Activation
dc.titleTumor necrosis factor primes neutrophils to kill Staphylococcus aureus by an oxygen-dependent mechanism and Plasmodium falciparum by an oxygen-independent mechanism
dc.typeJournal article
pubs.publication-statusPublished

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