Pruritogenic mechanisms and gut sensation: putting the "irritant" into irritable bowel syndrome

Date

2021

Authors

Brizuela, M.
Castro, J.
Harrington, A.M.
Brierley, S.M.

Editors

Advisors

Journal Title

Journal ISSN

Volume Title

Type:

Journal article

Citation

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2021; 320(6):G1131-G1141

Statement of Responsibility

Mariana Brizuela, Joel Castro, Andrea M. Harrington, and Stuart M. Brierley

Conference Name

DOI

10.1152/ajpgi.00331.2020

Abstract

Chronic abdominal pain is a common clinical condition experienced by patients with irritable bowel syndrome (IBS). A general lack of suitable treatment options for the management of visceral pain is the major contributing factor to the debilitating nature of the disease. Understanding the underlying causes of chronic visceral pain is pivotal to identifying new effective therapies for IBS. This review provides the current evidence, demonstrating that mediators and receptors that induce itch in the skin also act as "gut irritants" in the gastrointestinal tract. Activation of these receptors triggers specific changes in the neuronal excitability of sensory pathways responsible for the transmission of nociceptive information from the periphery to the central nervous system leading to visceral hypersensitivity and visceral pain. Accumulating evidence points to significant roles of irritant mediators and their receptors in visceral hypersensitivity and thus constitutes potential targets for the development of more effective therapeutic options for IBS.

School/Discipline

Dissertation Note

Provenance

Description

Access Status

Rights

© 2021 the American Physiological Society

License

Grant ID

http://purl.org/au-research/grants/nhmrc/1126378
 http://purl.org/au-research/grants/nhmrc/1083480
 http://purl.org/au-research/grants/nhmrc/1139366
 http://purl.org/au-research/grants/nhmrc/1140297
 http://purl.org/au-research/grants/nhmrc/1181448
 http://purl.org/au-research/grants/arc/DE130100223
 http://purl.org/au-research/grants/arc/DP180101395

Published Version

https://doi.org/10.1152/ajpgi.00331.2020

Call number

Persistent link to this record

http://hdl.handle.net/2440/131096