Pruritogenic mechanisms and gut sensation: putting the "irritant" into irritable bowel syndrome

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dc.contributor.authorBrizuela, M.
dc.contributor.authorCastro, J.
dc.contributor.authorHarrington, A.M.
dc.contributor.authorBrierley, S.M.
dc.date.issued2021
dc.description.abstractChronic abdominal pain is a common clinical condition experienced by patients with irritable bowel syndrome (IBS). A general lack of suitable treatment options for the management of visceral pain is the major contributing factor to the debilitating nature of the disease. Understanding the underlying causes of chronic visceral pain is pivotal to identifying new effective therapies for IBS. This review provides the current evidence, demonstrating that mediators and receptors that induce itch in the skin also act as "gut irritants" in the gastrointestinal tract. Activation of these receptors triggers specific changes in the neuronal excitability of sensory pathways responsible for the transmission of nociceptive information from the periphery to the central nervous system leading to visceral hypersensitivity and visceral pain. Accumulating evidence points to significant roles of irritant mediators and their receptors in visceral hypersensitivity and thus constitutes potential targets for the development of more effective therapeutic options for IBS.
dc.description.statementofresponsibilityMariana Brizuela, Joel Castro, Andrea M. Harrington, and Stuart M. Brierley
dc.identifier.citationAmerican Journal of Physiology - Gastrointestinal and Liver Physiology, 2021; 320(6):G1131-G1141
dc.identifier.doi10.1152/ajpgi.00331.2020
dc.identifier.issn0193-1857
dc.identifier.issn1522-1547
dc.identifier.orcidCastro, J. [0000-0002-5781-2224]
dc.identifier.orcidHarrington, A.M. [0000-0002-1562-4137]
dc.identifier.orcidBrierley, S.M. [0000-0002-2527-2905]
dc.identifier.urihttp://hdl.handle.net/2440/131096
dc.language.isoen
dc.publisherAmerican Physiological Society
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1126378
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1083480
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1139366
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1140297
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1181448
dc.relation.granthttp://purl.org/au-research/grants/arc/DE130100223
dc.relation.granthttp://purl.org/au-research/grants/arc/DP180101395
dc.rights© 2021 the American Physiological Society
dc.source.urihttps://doi.org/10.1152/ajpgi.00331.2020
dc.subjectGPCRs; histamine; itch; proteases; visceral hypersensitivity
dc.titlePruritogenic mechanisms and gut sensation: putting the "irritant" into irritable bowel syndrome
dc.typeJournal article
pubs.publication-statusPublished

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