Label-free bioaffinity detection using terahertz technology

Date

2002

Authors

Mickan, S.
Menikh, A.
Liu, H.
Mannella, C.
MacColl, R.
Abbott, D.
Munch, J.
Zhang, X.

Editors

Advisors

Journal Title

Journal ISSN

Volume Title

Type:

Journal article

Citation

Physics in Medicine and Biology, 2002; 47(21):3789-3795

Statement of Responsibility

Samuel P Mickan, Abdellah Menikh, Haibo Liu, Carmen A Mannella, Robert MacColl, Derek Abbott, Jesper Munch and X-C Zhang

Conference Name

DOI

10.1088/0031-9155/47/21/317

Abstract

We report the first use of differential terahertz time-domain spectroscopy for bioaffinity sensing. Binding is observed by measuring the transmission of a thin layer of biotin bound to the sensor protein avidin. We demonstrate the THz wave transmission of a sub-micron-thick film and sensitivity to 0.1 µg cm−2 of biotin. These results point the way for a host of biosensor applications using T-rays, or pulsed far-infrared (FIR) radiation.

School/Discipline

Dissertation Note

Provenance

Description

© 2002 IOP Publishing

Access Status

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Published Version

http://www.iop.org/EJ/abstract/0031-9155/47/21/317/

Call number

Persistent link to this record

http://hdl.handle.net/2440/2470