Label-free bioaffinity detection using terahertz technology

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dc.contributor.authorMickan, S.
dc.contributor.authorMenikh, A.
dc.contributor.authorLiu, H.
dc.contributor.authorMannella, C.
dc.contributor.authorMacColl, R.
dc.contributor.authorAbbott, D.
dc.contributor.authorMunch, J.
dc.contributor.authorZhang, X.
dc.date.issued2002
dc.description© 2002 IOP Publishing
dc.description.abstractWe report the first use of differential terahertz time-domain spectroscopy for bioaffinity sensing. Binding is observed by measuring the transmission of a thin layer of biotin bound to the sensor protein avidin. We demonstrate the THz wave transmission of a sub-micron-thick film and sensitivity to 0.1 µg cm−2 of biotin. These results point the way for a host of biosensor applications using T-rays, or pulsed far-infrared (FIR) radiation.
dc.description.statementofresponsibilitySamuel P Mickan, Abdellah Menikh, Haibo Liu, Carmen A Mannella, Robert MacColl, Derek Abbott, Jesper Munch and X-C Zhang
dc.identifier.citationPhysics in Medicine and Biology, 2002; 47(21):3789-3795
dc.identifier.doi10.1088/0031-9155/47/21/317
dc.identifier.issn0031-9155
dc.identifier.issn1361-6560
dc.identifier.orcidAbbott, D. [0000-0002-0945-2674]
dc.identifier.urihttp://hdl.handle.net/2440/2470
dc.language.isoen
dc.publisherIOP Publishing Ltd
dc.source.urihttp://www.iop.org/EJ/abstract/0031-9155/47/21/317/
dc.subjectMacromolecular Substances
dc.subjectAvidin
dc.subjectAffinity Labels
dc.subjectMembranes, Artificial
dc.subjectSensitivity and Specificity
dc.subjectRefractometry
dc.subjectSpectrum Analysis
dc.subjectBiosensing Techniques
dc.subjectProtein Binding
dc.subjectBiotin
dc.subjectElectromagnetic Phenomena
dc.subjectSurface Properties
dc.subjectMicrowaves
dc.subjectEquipment Design
dc.titleLabel-free bioaffinity detection using terahertz technology
dc.typeJournal article
pubs.publication-statusPublished

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